Results 91 to 100 of about 185,596 (291)

Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors

JAMA Network Open
ImportanceThe prognosis of advanced pancreaticobiliary tumors is poor. Next-generation sequencing (NGS) of tissue samples is utilized to identify actionable alterations, but there are occasional limitations due to inadequate tissue acquisition. Circulating tumor DNA (ctDNA) is an alternative method, but its correlation with tissue-based NGS remains ...
Mahadevia, Himil, Majeed, Umair, Patel, Jaydeepbhai, Ahmed, Ahmed K., Elhariri, Ahmed, Albelal, Douaa, Rao, Nakka Naga Malleswara, Rachamala, Hari Krishnareddy, Mosalem, Osama, Mukhopadhyay, Debabrata, Jones, Jeremy, Mahadevan, Daruka, Borad, Mitesh J., Ahn, Daniel, Sonbol, Mohamad Bassam, Tran, Nguyen, Mahipal, Amit, Wee Ma, Wen, McWilliams, Robert R., Halfdanarson, Thor R., Kankeu Fonkoua, Lionel A., Bekaii-Saab, Tanios, Mody, Kabir, Babiker, Hani   +23 more
openaire   +2 more sources

Circulating tumor DNA in advanced colorectal carcinoma patients [PDF]

, 2018
Colorectal carcinoma (CRC) is worldwide known as one of the most often tumor diseases. Approximately 50 % of patients are diagnosed with advanced stage of CRC and moreover even after removing all of the tumor bearings, there is high risk of its ...
Kopalová, Dominika
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignancies

, 2015
BACKGROUND: Circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), are both considered for blood-based mutation detection, but limited studies have compared them in a head-to-head manner. Using KRAS (Kirsten rat
Nicholson, Andrew G., Freidin, Maxim B.; id_orcid, Lim, Eric, Freydina, Dasha V.; id_orcid, Fernandez, Angeles Montero, Leung, Maria   +5 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Liquid biopsy in ovarian cancer: recent advances on circulating tumor cells and circulating tumor DNA

, 2017
Ovarian cancer remains the most lethal disease among gynecological malignancies despite the plethora of research studies during the last decades. The majority of patients are diagnosed in an advanced stage and exhibit resistance to standard chemotherapy.
Lydia Giannopoulou, Sabine Kasimir-Bauer, Evi S. Lianidou   +2 more
core   +2 more sources

Liquid Biopsy in Gastrointestinal Cancers

Diagnostics, 2018
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor ...
Aman Saini, Yash Pershad, Hassan Albadawi, Malia Kuo, Sadeer Alzubaidi, Sailendra Naidu, M-Grace Knuttinen, Rahmi Oklu   +7 more
doaj   +1 more source

Circulating free tumor DNA and colorectal cancer

, 2010
International audienceCancer is characterized by multiple somatic genetic and epigenetic alterations that could be useful as molecular markers for detecting tumor DNA in different bodily fluids.
Lecomte, Thierry, Laurent-Puig, Pierre, Ceze, Nicolas, Dorval, Etienne   +3 more
core  

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?

, 2014
Next-generation sequencing studies have provided further evidence to support the notion that cancer is a disease characterized by Darwinian evolution. Today, we often fail to capture this evolution and treatment decisions, even in the metastatic setting,
Ignatiadis, Michail, Dawson, Sarah Jane
core   +1 more source

Supplementary Data from Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma

, 2021
Supplementary Data from Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell ...
John N. Waldron (15032258), Daniel D. De Carvalho (15032261), Sareh Keshavarzi (5143991), Ilan Weinreb (5166416), Lillian L. Siu (14851075), Wei Xu (28953), Yangqiao Zheng (15032249), David P. Goldstein (9316874), Zhen Zhao (159931), Michael M. Hoffman (12856916), Justin M. Burgener (11502472), Jinfeng Zou (201031), Fei-Fei Liu (9030140), Geoffrey Liu (9416973), Anna Spreafico (4823517), John R. de Almeida (3805210), Shu Yi Shen (15032252), Scott V. Bratman (14936316), Shao Hui Huang (15032255)   +18 more
core   +1 more source