Results 71 to 80 of about 186,683 (292)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Circulating free tumor DNA and colorectal cancer [PDF]

, 2010
International audienceCancer is characterized by multiple somatic genetic and epigenetic alterations that could be useful as molecular markers for detecting tumor DNA in different bodily fluids.
Lecomte, Thierry, Laurent-Puig, Pierre, Ceze, Nicolas, Dorval, Etienne   +3 more
core  

Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality? [PDF]

, 2014
Next-generation sequencing studies have provided further evidence to support the notion that cancer is a disease characterized by Darwinian evolution. Today, we often fail to capture this evolution and treatment decisions, even in the metastatic setting,
Ignatiadis, Michail, Dawson, Sarah Jane
core   +1 more source

Supplementary Data from Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma [PDF]

, 2021
Supplementary Data from Tumor-Naïve Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell ...
John N. Waldron (15032258), Daniel D. De Carvalho (15032261), Sareh Keshavarzi (5143991), Ilan Weinreb (5166416), Lillian L. Siu (14851075), Wei Xu (28953), Yangqiao Zheng (15032249), David P. Goldstein (9316874), Zhen Zhao (159931), Michael M. Hoffman (12856916), Justin M. Burgener (11502472), Jinfeng Zou (201031), Fei-Fei Liu (9030140), Geoffrey Liu (9416973), Anna Spreafico (4823517), John R. de Almeida (3805210), Shu Yi Shen (15032252), Scott V. Bratman (14936316), Shao Hui Huang (15032255)   +18 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes. [PDF]

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability.
Xin Hu (38924), Yuanxin Xi (255031), Pedro Rocha (386032), Monique B Nilsson (18126607), Yael Raviv (18126616), Veronique Hofman (258841), John V Heymach (13586320), Mina Gaga (2938956), Bingnan Zhang (15161805), Paul Hofman (103032), Christine M Lovly (18126598), Edurne Arriola (632850), Jing Wang (6206297), Vasileios Panagoulias (18126613), Jianjun Zhang (220300), Marcos R Estecio (18126589), Hai Tran (470946), Kyle Concannon (15162981), Ignacio I Wistuba (18126622), Maria Gabriela Raso (14886905), Catherine A Schnabel (18126619), Peter Van Loo (9838), Azusa Tanimoto (14936243), Lixia Diao (184400), Natalie I Vokes (17808782), Adam Wasserstrom (27739), Whitney Elisabeth Lewis (18126604), Kimie Kondo (195898), Simon Heeke (8460396), Danny Frumkin (15144570), Prasad Kopparapu (524553), Ildikó Horváth (530804), Maarten Jansen (18126610), Qi Wang (22418), Benjamin B Morris (18126592), Allison Stewart (50114), Carl M Gay (18126586), Siqi Lai (18126595), Luana Guimaraes De Sousa (18126601), Aharona Shuali (15144567), Ximing Tang (253548), Lauren A Byers (17532391)   +41 more
core   +1 more source

Liquid biopsy for cancer management: a revolutionary but still limited new tool for precision medicine

Advances in Laboratory Medicine, 2020
The term liquid biopsy is used in contraposition to the traditional “solid” tissue biopsy. In the oncology field it has opened a new plethora of clinical opportunities as tumor-derived material is shedded into the different biofluids from where it can be
Arechederra María, Ávila Matías A., Berasain Carmen   +2 more
doaj   +1 more source

Circulating Tumor DNA in Cervical Cancer: Clinical Utility and Medico-Legal Perspectives. [PDF]

Oncol Res
Cervical cancer related to human papillomavirus (HPV) is a leading cause of cancer-related mortality among women worldwide. Cancer cells release fragments of their DNA, known as circulating tumor DNA (ctDNA), which can be detected in bodily fluids.
Sinno AK, Mustapha A, Nair N, Zaami S, Paola L, Billone V, Conti E, Gullo G, Patrizio P.   +8 more
europepmc   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source