Results 71 to 80 of about 3,179,450 (287)

Supplementary Table 3 from Concordance and Clinical Significance of Genomic Alterations in Progressive Tumor Tissue and Matched Circulating Tumor DNA in Aggressive-variant Prostate Cancer

, 2023
Copy Number Variants Detected in Progressive Tumor Tissue and Matched Circulating Tumor DNA for Each AVPC Patient.
Guang Xu (17333376), Jun Xie (17333382), Ruiliang Wang (17333340), Hong Wang (17333355), Xudong Yao (17333397), Xiaoying Zhang (17333370), Bin Yang (17333400), Yanyan He (17333367), Tingting Zhao (17333385), Guanjie Yang (17333349), Jun Zhang (17333352), Jing Yuan (17333364), Hongliang Fu (17333373), Changcheng Guo (17333361), Longfei Huang (17333388), Qiufan Xu (17333343), Bo Peng (17333394), Tianyuan Xu (17333358), Jiansheng Zhang (17333391), Hanxu Guo (17333346), Binghui Zhao (17333379)   +20 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Circulating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility [PDF]

Clinical Cancer Research, 2015
Abstract Recent technological advances have enabled the detection and detailed characterization of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from patients with cancer. Often referred to as a “liquid biopsy,” CTCs and ctDNA are expected to provide real-time monitoring of tumor evolution and ...
Ignatiadis, Michail, Lee, Mark, Jeffrey, Stefanie S.S.   +2 more
openaire   +3 more sources

Supplementary Table 2 from Concordance and Clinical Significance of Genomic Alterations in Progressive Tumor Tissue and Matched Circulating Tumor DNA in Aggressive-variant Prostate Cancer

, 2023
Somatic Mutations and Deleterious Germline Mutations Detected in Progressive Tumor Tissue and Matched Circulating Tumor DNA for Each AVPC Patient.
Guang Xu (17333376), Jun Xie (17333382), Ruiliang Wang (17333340), Hong Wang (17333355), Xudong Yao (17333397), Xiaoying Zhang (17333370), Bin Yang (17333400), Yanyan He (17333367), Tingting Zhao (17333385), Guanjie Yang (17333349), Jun Zhang (17333352), Jing Yuan (17333364), Hongliang Fu (17333373), Changcheng Guo (17333361), Longfei Huang (17333388), Qiufan Xu (17333343), Bo Peng (17333394), Tianyuan Xu (17333358), Jiansheng Zhang (17333391), Hanxu Guo (17333346), Binghui Zhao (17333379)   +20 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Variant allele fraction of genomic alterations in circulating tumor DNA (%ctDNA) correlates with SUV [PDF]

, 2021
The relationship between higher variant allele fraction (VAF) of genomic alterations in circulating tumor DNA (%ctDNA), an indicator of poor outcome, and maximum standardized uptake value ...
Haghighat Jahromi, Amin, Okamura, Ryosuke, Hoh, Carl K, Zabel, Matthew, Kurzrock, Razelle   +4 more
core   +1 more source

Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors

Therapeutic Advances in Medical Oncology, 2019
In recent years, growing research interest has focused on the so-called liquid biopsy. A simple blood test offers access to a plethora of information, which might be extremely helpful in understanding or characterizing specific diseases.
Gloria Ravegnini, Giulia Sammarini, César Serrano, Margherita Nannini, Maria A. Pantaleo, Patrizia Hrelia, Sabrina Angelini   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source