Results 61 to 70 of about 186,683 (292)

promoter mutations in circulating tumor DNA [PDF]

, 2020
Background and Aim Human telomerase reverse transcriptase (TERT) promoter mutations were the most prevalent mutations in patients with hepatocellular carcinoma (HCC).
Yamamoto, Shumpei, Okada, Hiroyuki, Kinugasa, Hideaki, Atsushi Oyama, Hiroyuki Okada, Hiroyuki Terasawa, Onishi, Hideki, Wada, Nozomu, Masahiro Sakata, Hideki Onishi, Adachi, Takuya, Oyama, Atsushi, Mami Hirai, Akinobu Takaki, Takaki, Akinobu, Nouso, Kazuhiro, Yuma Onishi, Takuya Adachi, Yasunaka, Tetsuya, Nozomu Wada, Hidenori Shiraha, Shiraha, Hidenori, Terasawa, Hiroyuki, Onishi, Yuma, Sakata, Masahiro, Hirai, Mami, Kazuhiro Nouso, Shumpei Yamamoto, Hideaki Kinugasa, Tetsuya Yasunaka   +29 more
core   +1 more source

Liquid biopsy in gallbladder carcinoma: Current evidence and future prospective

The Journal of Liquid Biopsy
Although there have been significant advances in the early detection and treatment of gallbladder cancer (GBC), it is still considered a leading cause of morbidity and mortality. Molecular profiling of tumors is generally performed using samples obtained
Sridhar Mishra, Swati Kumari, Nuzhat Husain   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circulating tumor DNA outperforms circulating tumor cells for KRAS mutation detection in thoracic malignancies [PDF]

, 2015
BACKGROUND: Circulating biomarkers, such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), are both considered for blood-based mutation detection, but limited studies have compared them in a head-to-head manner. Using KRAS (Kirsten rat
Nicholson, Andrew G., Freidin, Maxim B.; id_orcid, Lim, Eric, Freydina, Dasha V.; id_orcid, Fernandez, Angeles Montero, Leung, Maria   +5 more
core   +1 more source

Tumor-informed ctDNA surveillance after radical nephrectomy and level IV IVC thrombectomy for clear cell renal cell carcinoma: Early detection of molecular residual disease

Urology Case Reports
Renal cell carcinoma with level IV inferior vena cava tumor thrombus is rare and associated with high recurrence risk despite complete resection. We report an 80-year-old man who underwent radical nephrectomy and inferior vena cava thrombectomy with ...
Mahdi Hemmati Ghavshough, Melinda Z. Fu, Disha Patel, Vignesh T. Packiam, Saum Ghodoussipour   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Liquid biopsy in ovarian cancer: recent advances on circulating tumor cells and circulating tumor DNA [PDF]

, 2017
Ovarian cancer remains the most lethal disease among gynecological malignancies despite the plethora of research studies during the last decades. The majority of patients are diagnosed in an advanced stage and exhibit resistance to standard chemotherapy.
Lydia Giannopoulou, Sabine Kasimir-Bauer, Evi S. Lianidou   +2 more
core   +3 more sources

Potential role of circulating tumor cells and cell-free DNA as biomarkers in oral squamous cell carcinoma: A prospective single-center study.

PLoS ONE
Metastasis in patients with oral squamous cell carcinoma has been associated with a poor prognosis. However, sensitive and reliable tests for monitoring their occurrence are unavailable, with the exception of PET-CT. Circulating tumor cells and cell-free
Natsuki Eboshida, Atsuko Hamada, Mirai Higaki, Fumitaka Obayashi, Nanako Ito, Sachiko Yamasaki, Ryouji Tani, Tomoaki Shintani, Koichi Koizumi, Souichi Yanamoto   +9 more
doaj   +1 more source

Clinical applications of circulating tumor DNA and circulating tumor cells in pancreatic cancer [PDF]

Molecular Oncology, 2016
Pancreatic ductal adenocarcinoma (PDAC) is the most frequent pancreatic cancer type and is characterized by a dismal prognosis due to late diagnosis, local tumor invasion, frequent distant metastases and poor sensitivity to current therapy. In this context, circulating tumor cells and circulating tumor DNA constitute easily accessible blood‐borne tumor
Riva, Francesca; Dronov, Oleksii I.; Khomenko, Dmytro I.; Huguet, Florence; Louvet, Christophe; Mariani, Pascale; Stern, Marc-Henri; Lantz, Olivier; Proudhon, Charlotte; Pierga, Jean-yves; Bidard, Francois-Clement   +11 more
openaire   +2 more sources