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Circulating Tumor Cell Detection for Therapeutic and Prognostic Roles in Breast Cancer [PDF]

Cancer Medicine
Background Circulating tumor cells (CTCs) are pivotal liquid biopsy (LB) biomarkers for breast cancer (BC), offering non‐invasive insights into tumor progression and metastasis.
Saiying Ma, Xiaojia Wang, Peter Ping Lin, Lei Lei   +3 more
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Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Purpose: Monocarboxylate transporter 4 (MCT4) can influence the amount of lactate in the tumor microenvironment and further control cancer cell proliferation, migration, and angiogenesis.
Athina Markou, E. Tzanikou, G. Kallergi, E. Pantazaka, V. Georgoulias, A. Kotsakis, E. Lianidou   +6 more
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Comprehensive liquid biopsy analysis as a tool for the early detection of minimal residual disease in breast cancer

Scientific Reports, 2023
Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou, Athina Markou, Areti Strati, Martha Zavridou, Eleni Tzanikou, Sophia Mastoraki, Galatea Kallergi, Vassilis Georgoulias, Evi Lianidou   +8 more
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PD-L1/pS6 in Circulating Tumor Cells (CTCs) during Osimertinib Treatment in Patients with Non-Small Cell Lung Cancer (NSCLC)

Biomedicines, 2022
The PD-1/PD-L1 axis provides CTCs an escape route from the immune system. Phosphorylation of the ribosomal protein S6 is implicated in the same pathway, following mTOR activation. The aim of the study was to investigate the expression of PD-L1 and pS6 in
Evangelia Pantazaka, Aliki Ntzifa, Argyro Roumeliotou, Evi Lianidou, Vassilis Georgoulias, Athanasios Kotsakis, Galatea Kallergi   +6 more
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Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

Scientific Reports, 2021
Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under osimertinib.
Aliki Ntzifa, Areti Strati, Galatea Kallergi, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou   +5 more
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The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer

Frontiers in Endocrinology, 2022
Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract worldwide and is a serious threat to human life and health. CRC occurs and develops in a multi-step, multi-stage, and multi-gene process, in which abnormal gene ...
JinHua He, NaiTe Xi, ZePing Han, WenFeng Luo, Jian Shen, ShengBo Wang, JianHao Li, ZhongHui Guo, HanWei Cheng   +8 more
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Enrichment of Circulating Tumor Cells of Lung Cancer and Correlation With Serum Leukomonocyte and Tumor Biomarkers: A Retrospective Study

Technology in Cancer Research & Treatment, 2023
Study design Circulating tumor cells is important in the clinical diagnosis of cancer and there are a number of circulating tumor cell detection systems associated with different isolation strategies being validated.
Zhou-Fang Mei MD, Jing Yan PhD, Ling Qian MD, Yan-Chao He MD, Jing-Jing Feng MD, Jie Wang PhD, Zhi-Jun Jie PhD, Hua Zou PhD   +7 more
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The Value of Circulating Tumor Cells in the Prognosis and Treatment of Pancreatic Cancer

Frontiers in Oncology, 2022
In the past few decades, tumor diagnosis and treatment theory have developed in a variety of directions. The number of people dying from pancreatic cancer increases while the mortality rate of other common tumors decreases.
Kai Luo, Xiangkun Wang, Xudong Zhang, Zhongyuan Liu, Shuai Huang, Renfeng Li   +5 more
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The Value of Circulating Tumor Cells and Tumor Markers Detection in Lung Cancer Diagnosis

Technology in Cancer Research & Treatment, 2023
Objective Circulating tumor cells are complete tumor cells with multi-scale analysis values that present a high potential for lung cancer diagnosis. To enhance the accuracy of lung cancer diagnosis, we detected circulating tumor cells by the innovated ...
Sumin Guo MD, Jingyu Chen BS, Po Hu MD, Chen Li MD, Xiang Wang MD, Ning Chen PhD, Jiale Sun, Yongfeng Wang BS, Jianling Wang BS, Weikuan Gu PhD, Shucai Wu MD   +10 more
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Minimal residual disease in prostate cancer patients after primary treatment: theoretical considerations, evidence and possible use in clinical management

Biological Research, 2018
Minimal residual disease is that not detected by conventional imaging studies and clinically the patient remains disease free. However, with time these dormant cells will awaken and disease progression occurs, resulting in clinically and radiological ...
Nigel P. Murray
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