Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry [PDF]
Scientific Reports, 2017 Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from blood ...
Sam H. Au +9 more
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Single Cell Analysis of Inertial Migration by Circulating Tumor Cells and Clusters
Micromachines, 2023 Single-cell analysis provides a wealth of information regarding the molecular landscape of the tumor cells responding to extracellular stimulations, which has greatly advanced the research in cancer biology.
Jian Zhou +3 more
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Novel approaches in cancer management with circulating tumor cell clusters [PDF]
Journal of Science: Advanced Materials and Devices, 2019 Tumor metastasis is responsible for the vast majority of cancer-associated morbidities and mortalities. Recent studies have disclosed the higher metastatic potential of circulating tumor cell (CTC) clusters than single CTCs.
Peyman Rostami +5 more
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Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy [PDF]
Acta Pharmaceutica Sinica B, 2021 Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death. Moreover, circulating tumor cell (CTC) clusters play a pivotal role in tumor metastasis.
Dan Li +7 more
doaj +4 more sources
Label‐Free Microfluidic Apheresis of Circulating Tumor Cell Clusters [PDF]
Advanced ScienceScreening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which are known to be highly metastasis‐competent, yet ultrarare.
Li Zhan +3 more
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In Vitro Model-Systems to Understand the Biology and Clinical Significance of Circulating Tumor Cell Clusters [PDF]
Frontiers in Oncology, 2018 The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells.
Alexander N. May +2 more
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High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells [PDF]
Nature Communications, 2022 Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retrieval
Mert Boya +18 more
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Label-free flow cytometry of rare circulating tumor cell clusters in whole blood [PDF]
Scientific Reports, 2022 Circulating tumor cell clusters (CTCCs) are rare cellular events found in the blood stream of metastatic tumor patients. Despite their scarcity, they represent an increased risk for metastasis.
Nilay Vora +4 more
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Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines [PDF]
BMC CancerBackground Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress.
Jueyao Zou +11 more
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Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α–DSG2 signaling [PDF]
Experimental and Molecular Medicines Circulating tumor cell (CTC) clusters, key in metastasis, rely on intercellular junctions for stability. However, the specific mechanisms governing intercellular connections within CTC clusters and the strategy targeting intercellular junctions to ...
Jueyao Zou +14 more
doaj +2 more sources