Clinical significance and heterogeneity of circulating tumor cells and clusters in breast cancer subtypes [PDF]
PeerJThe marked heterogeneity of breast cancer results in substantial variations in clinical characteristics, metastatic patterns, and prognosis across molecular subtypes.
LiangYu Hao, Lixiang Zheng
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Targeting Src/FN1 adhesion circuitry to suppress circulating tumor cell clusters and lung cancer metastasis [PDF]
Genes and DiseasesPing Lin, Jianxin Jiang, Min Wu
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Better together: circulating tumor cell clustering in metastatic cancer [PDF]
Trends in Cancer, 2021 Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific dogma focuses on metastasis mediated by single CTCs, but advancement of CTC detection technologies has elucidated multicellular CTC clusters, which are associated with ...
Schuster, Emma +5 more
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Role of circulating tumor cell clusters in breast cancer. [PDF]
Transl Breast Cancer ResHamilton G, Eggerstorfer MT, Stickler S.
europepmc +2 more sources
Modeling the dynamics of circulating tumor cell clusters inside a microfluidic channel. [PDF]
BiomicrofluidicsCirculating tumor cells are central to metastasis, a particularly malign spread of cancer beyond its original location. While rare, there is growing evidence that the clusters of circulating tumor cells are significantly more harmful than individual cells.
Ezeobidi EI, Truszkowska A.
europepmc +3 more sources
Mitotic arrest affects clustering of tumor cells
Cell Division, 2021 Background Cancer cell aggregation is a key process involved in the formation of tumor cell clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an increased metastatic potential compared to isolated circulating tumor
Julia Bonnet +7 more
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The Effect of Lung Resection for NSCLC on Circulating Immune Cells: A Pilot Study
Current Oncology, 2023 This pilot study sought to evaluate the circulating levels of immune cells, particularly regulatory T-cell (Treg) subsets, before and after lung resection for non-small cell lung cancer.
Joseph D. Phillips +10 more
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Nature Communications, 2021 Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer.
Rokana Taftaf +21 more
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Dangerous Liaisons: Circulating Tumor Cells (CTCs) and Cancer-Associated Fibroblasts (CAFs) [PDF]
, 2020 The crosstalk between cancer cells and the tumor microenvironment (TME) is a key determinant of cancer metastasis. Cancer-associated fibroblasts (CAFs), one of the main cellular components of TME, promote cancer cell invasion and dissemination through ...
Martínez Pena, Inés +5 more
core +1 more source
Endogenous light scattering as an optical signature of circulating tumor cell clusters. [PDF]
Biomed Opt Express, 2016 Circulating tumor cell clusters (CTCCs) are significantly more likely to form metastases than single tumor cells. We demonstrate the potential of backscatter-based flow cytometry (BSFC) to detect unique light scattering signatures of CTCCs in the blood of mice orthotopically implanted with breast cancer cells and treated with an anti-ADAM8 or a control
Lyons J +5 more
europepmc +3 more sources