Results 11 to 20 of about 6,850,236 (255)

Circulating Tumor Cell Clusters: United We Stand Divided We Fall. [PDF]

Int J Mol Sci, 2020
International audienceThe presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described.
Amintas S, Bedel A, Moreau-Gaudry F, Boutin J, Buscail L, Merlio JP, Vendrely V, Dabernat S, Buscail E.   +8 more
europepmc   +8 more sources

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. [PDF]

Cell, 2014
SummaryCirculating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined.
Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S.   +19 more
europepmc   +8 more sources

Discovery and characterization of circulating tumor cell clusters in neuroendocrine tumor patients using nanosubstrate-embedded microchips. [PDF]

Biosens Bioelectron, 2022
Circulating tumor cell (CTC) clusters are present in cancer patients with severe metastasis, resulting in poor clinical outcomes. However, CTC clusters have not been studied as extensively as single CTCs, and the clinical utility of CTC clusters remains ...
Sun N, Yang Y, Miao H, Redublo P, Liu H, Liu W, Huang YW, Teng PC, Zhang C, Zhang RY, Smalley M, Yang P, Chou SJ, Huai K, Zhang Z, Lee YT, Wang JJ, Wang J, Liang IY, Zhang TX, Zhang D, Liang L, Weiss PS, Posadas EM, Donahue T, Hecht JR, Allen-Auerbach MS, Bergsland EK, Hope TA, Pei R, Zhu Y, Tseng HR, Heaney AP.   +32 more
europepmc   +4 more sources

c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis [PDF]

Biological Procedures Online
Background Circulating tumor cells (CTCs) serve as the “seeds” of tumor metastasis, and the clustering of CTCs is critically associated with tumor metastasis and the mortality of lung cancer patients.
Zhipeng Zhang, Xinyi Lu, Jianhui Tian, Jiaxuan Li, Shihui Liu, Jiajun Liu, Bin Luo, Jialiang Yao, Yao Liu, Yanhong Wang, Wang Yao, Yun Yang, Wenji Shangguan, Zujun Que   +13 more
doaj   +3 more sources

Circulating Tumor Cell Clusters Are Frequently Detected in Women with Early-Stage Breast Cancer. [PDF]

Cancers (Basel), 2021
The clinical relevance of circulating tumor cell clusters (CTC-clusters) in breast cancer (BC) has been mostly studied using the CellSearch®, a marker-dependent method detecting only epithelial-enriched clusters. However, due to epithelial-to-mesenchymal
Reduzzi C, Di Cosimo S, Gerratana L, Motta R, Martinetti A, Vingiani A, D'Amico P, Zhang Y, Vismara M, Depretto C, Scaperrotta G, Folli S, Pruneri G, Cristofanilli M, Daidone MG, Cappelletti V.   +15 more
europepmc   +4 more sources

Metastasis Stemming from Circulating Tumor Cell Clusters. [PDF]

Trends Cell Biol, 2019
Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel ...
Yu M.
europepmc   +5 more sources

Intratumor Heterogeneity and Circulating Tumor Cell Clusters [PDF]

Molecular Biology and Evolution, 2017
SummaryGenetic diversity plays a central role in tumor progression, metastasis, and resistance to treatment. Experiments are shedding light on this diversity at ever finer scales, but interpretation is challenging.
Simon Gravel, Zafarali Ahmed
core   +3 more sources

Insights into Circulating Tumor Cell Clusters: A Barometer for Treatment Effects and Prognosis for Prostate Cancer Patients. [PDF]

Cancers (Basel), 2022
SIMPLE SUMMARY: Circulating tumor cells (CTCs) are a promising biomarker for the risk of prostate cancer aggressiveness and metastasis and play a role in the processes of tumor migration and metastasis.
Lu L, Hu W, Liu B, Yang T.
europepmc   +3 more sources

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters. [PDF]

Nat Genet
Circulating tumor cell (CTC) clusters are highly efficient metastatic seeds in various cancers. Yet, their genetic heterogeneity and clonal architecture is poorly characterized.
Gremmelspacher D, Gawron J, Szczerba BM, Jahn K, Castro-Giner F, Kuipers J, Singer J, Marass F, Gvozdenovic A, Budinjas S, Pueschel H, Rentsch CA, Zippelius A, Heinzelmann-Schwarz V, Kurzeder C, Weber WP, Rochlitz C, Vetter M, Beerenwinkel N, Aceto N.   +19 more
europepmc   +5 more sources

Algorithm to identify circulating tumor cell clusters using in vivo flow cytometer [PDF]

Journal of Innovative Optical Health Sciences, 2018
Recent studies in oncology have addressed the importance of detecting circulating tumor cell clusters because circulating tumor cell clusters might survive and metastasize more easily than single circulating tumor cells.
Kai Pang, Dan Wei, Pengfei Hai, Zhangru Yang, Xiaofu Weng, Xunbin Wei   +5 more
doaj   +2 more sources