Tumor‐derived proliferative CTCs and CTC clusters predict aggressiveness and early recurrence in hepatocellular carcinoma patients [PDF]
Cancer Medicine, 2023 Background Circulating tumor cells (CTCs), an indispensable liquid biopsy classifier, can provide extra information for the diagnosis and prognosis of hepatocellular carcinoma (HCC). Methods We systematically analyzed the peripheral blood of preoperative
Lina Zhao +13 more
doaj +3 more sources
Regulating chemoresistance and cancer stemness: the CDH17-YAP pathway in distinct cellular states of lung cancer CTC clusters [PDF]
Cellular & Molecular Biology LettersBackground Drug resistance in metastatic lung cancer significantly contributes to patient mortality. This study explores the role of circulating tumor cells (CTCs), the precursors to metastasis, in driving this resistance.
Zujun Que +11 more
doaj +3 more sources
High-Throughput Label-Free Isolation of Heterogeneous Circulating Tumor Cells and CTC Clusters From Non-Small-Cell Lung Cancer Patients [PDF]
Cancers, 2020 (1) Background: Circulating tumor cell (CTC) clusters are emerging as clinically significant harbingers of metastases in solid organ cancers. Prior to engaging these CTC clusters in animal models of metastases, it is imperative for technology to identify
Mathias Hafner +2 more
exaly +6 more sources
Sequential Isolation and Characterization of Single CTCs and Large CTC Clusters in Metastatic Colorectal Cancer Patients [PDF]
Cancers, 2021 Circulating tumor cells (CTCs) detach from a primary tumor or its metastases and circulate in the bloodstream. The vast majority of CTCs are deemed to die into the bloodstream, with only few cells representing viable metastatic precursors.
Valentina Magri +2 more
exaly +5 more sources
Analysis of a Real-World Cohort of Metastatic Breast Cancer Patients Shows Circulating Tumor Cell Clusters (CTC-Clusters) as Predictors of Patient Outcomes [PDF]
Cancers, 2020 Circulating tumor cell (CTC) enumeration has emerged as a powerful biomarker for the assessment of prognosis and the response to treatment in metastatic breast cancer (MBC).
Inés Martínez-Peña +2 more
exaly +4 more sources
Correlation Between Circulating Tumor Cell DNA Genomic Alterations and Mesenchymal CTCs or CTC-Associated White Blood Cell Clusters in Hepatocellular Carcinoma [PDF]
Frontiers in Oncology, 2021 PurposeLiquid biopsy is attracting attention as a method of real-time monitoring of patients with tumors. It can be used to understand the temporal and spatial heterogeneity of tumors and has good clinical application prospects. We explored a new type of
Chunming Wang +7 more
doaj +4 more sources
CTC Clusters Induced by Heparanase Enhance Breast Cancer Metastasis [PDF]
Acta Pharmacologica Sinica, 2018 Aggregated metastatic cancer cells, referred to as circulating tumor cell (CTC) clusters, are present in the blood of cancer patients and contribute to cancer metastasis.
Xiong Zhang, Xun Huang, Mei-Yu Geng
exaly +4 more sources
BMC Cancer, 2021 Purpose Circulating tumour cell (CTC) and CTC-white blood cell (CTC-WBC) clusters are related to the prognosis of tumour patients. However, the relationship between CTC-WBC clusters and prognosis in renal cell carcinoma (RCC) patients is not clear.
Yibing Guan +8 more
doaj +2 more sources
Association of a novel circulating tumor DNA next-generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer [PDF]
Breast Cancer Research, 2019 Purpose Liquid biopsies, including circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), can be used to understand disease prognosis, tumor heterogeneity, and dynamic response to treatment in metastatic breast cancer (MBC).
Andrew A. Davis +11 more
doaj +2 more sources
Breast Cancer ResearchBackground Circulating tumor cell (CTC) clusters exhibit significantly greater metastatic potential than single CTCs and are associated with poorer overall survival in cancers.
Lihuang Guo +7 more
doaj +2 more sources