Results 41 to 50 of about 714,192 (184)

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

Nature Communications, 2021
Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer.
Rokana Taftaf, Xia Liu, Salendra Singh, Yuzhi Jia, Nurmaa K. Dashzeveg, Andrew D. Hoffmann, Lamiaa El-Shennawy, Erika K. Ramos, Valery Adorno-Cruz, Emma J. Schuster, David Scholten, Dhwani Patel, Youbin Zhang, Andrew A. Davis, Carolina Reduzzi, Yue Cao, Paolo D’Amico, Yang Shen, Massimo Cristofanilli, William A. Muller, Vinay Varadan, Huiping Liu   +21 more
doaj   +1 more source

Phenotype of Primary Tumors in CTC Clusters.

, 2012
Phenotype of Primary Tumors in CTC Clusters.
Ranjana H. Advani (167107), Glenn Deng (167101), Ashley A. Powell (167086), AmirAli H. Talasaz (122003), Haiyu Zhang (167092), Michael N. Mindrinos (82787), Robert W. Carlson (167112), Stefanie S. Jeffrey (167122), Shanaz H. Dairkee (167120), R. Fabian Pease (167119), Gyan Bhanot (34639), Ronald W. Davis (12925), Stephen R. Quake (102383), Anupama Reddy (118897), Shruti Sheth (167117), Frank E. Stockdale (167118), Marc A. Coram (167094), Melinda L. Telli (167105), James M. Ford (136395), Joseph A. Mollick (167115), Allison W. Kurian (136390)   +20 more
core   +1 more source

High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells

Nature Communications, 2022
Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retrieval
Mert Boya, Tevhide Ozkaya-Ahmadov, Brandi E. Swain, Chia-Heng Chu, Norh Asmare, Ozgun Civelekoglu, Ruxiu Liu, Dohwan Lee, Sherry Tobia, Shweta Biliya, L. DeEtte McDonald, Bassel Nazha, Omer Kucuk, Martin G. Sanda, Benedict B. Benigno, Carlos S. Moreno, Mehmet A. Bilen, John F. McDonald, A. Fatih Sarioglu   +18 more
doaj   +1 more source

High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device.

PLoS ONE, 2021
Metastasis represents a dynamic succession of events involving tumor cells which disseminate through the organism via the bloodstream. Circulating tumor cells (CTCs) can flow the bloodstream as single cells or as multicellular aggregates (clusters ...
Alessandra Marrella, Arianna Fedi, Gabriele Varani, Ivan Vaccari, Marco Fato, Giuseppe Firpo, Patrizia Guida, Nicola Aceto, Silvia Scaglione   +8 more
doaj   +1 more source

Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated‐Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC

Advanced Science, 2022
Eliminating primary tumor (“roots”) and inhibiting associated‐circulating tumor cells (associated‐CTCs, “seeds”) are vital issues that need to be urgently addressed in cancer therapy.
Weiwei Mu, Qihui Chu, Huizhen Yang, Li Guan, Shunli Fu, Tong Gao, Xiao Sang, Zipeng Zhang, Shuang Liang, Yongjun Liu, Na Zhang   +10 more
doaj   +1 more source

Supporting Information for CTC clusters in early lung cancer from Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early-Stage Lung Cancers

, 2017
Supporting information showing CTC enumeration and gene expression profiling data for CTC clusters from early stage lung cancer.
Shamileh Fouladdel (4011116), Nallasivam Palanisamy (265021), Philip Carrott (14928120), Jules Lin (4876522), William R. Lynch (5474588), Sunitha Nagrath (11526790), Vasudha Murlidhar (14928111), Chandan Kumar-Sinha (228759), Rishindra M. Reddy (5474594), Zhuo Zhang (72795), Max S. Wicha (8815442), Andrew C. Chang (5474591), Martin K. Ishikawa (14928114), Ebrahim Azizi (4011107), Nithya Ramnath (65240), Lili Zhao (442802), David G. Beer (8537520), Svetlana Grabauskiene (14928117), Mark B. Orringer (5474585)   +18 more
core   +1 more source

Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines

BMC Cancer
Background Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress.
Jueyao Zou, Qiong Chen, Yong He, Yanhong Pan, Han Zhao, Junfeng Shi, Zhonghong Wei, Suyun Yu, Yang Zhao, Xin Han, Yin Lu, Wenxing Chen   +11 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Acoustic enrichment of heterogenous circulating tumor cells and clusters from patients with metastatic prostate cancer

, 2023
BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity.
Welén, Karin, Ceder, Yvonne, Magnusson, Cecilia, Bjartell, Anders, Laurell, Thomas, Josefsson, Andreas, Undvall Anand, Eva, Lilja, Hans, Augustsson, Per, Lenshof, Andreas, Lenshof, Andreas,, Josefsson, Andreas,, Augustsson, Per,, Anand, Eva Undvall, Magnusson, Cecilia,, Lilja, Hans,, Laurell, Thomas,, Undvall Anand, Eva,, Bjartell, Anders,, Welén, Karin,, Ceder, Yvonne,, Lund University.   +21 more
core   +2 more sources

Circulating tumor cells and clusters as liquid biomarkers for the diagnosis and prognosis of neuroblastoma

BMC Cancer
Background The clinical significance of circulating tumor cell (CTC) clusters in highly metastatic tumors hasn’t yet been revealed. Here, we demonstrated the diagnostic and prognostic value of CTC clusters in neuroblastoma (NB) which is the most ...
Huanli Xu, Nianhua Cao, Wenyan Dai, Caiwei Sima, Meng Yi, Senmin Chen, Xiaowen Chen, Chao Liu, Uet Yu, Huiping Lang, Zhedie Zhou, Nanlin Yang, Chunjing Wang, Xianping Jiang, Yungen Gan, Jianyao Wang, Yuanxiang Wang, Nuaner Yao, Lidan Xiao, Qing Zhang, Junjie Sun, Zhou Lin, Gongwei Zhang, Jiayue Zhang, Hongtao Feng, Jianming Song, Sixi Liu, Zongbin Liu, Feiqiu Wen, Xiuli Yuan   +29 more
doaj   +1 more source