Results 11 to 20 of about 714,192 (184)

Post-therapeutic circulating tumor cell-associated white blood cell clusters predict poor survival in patients with advanced driver gene-negative non-small cell lung cancer

BMC Cancer, 2023
Purpose This study aimed to investigate the clinical utility of diverse aneuploid circulating tumor cell (CTC) subtypes and particularly CTC-associated white blood cell (CTC-WBC) clusters in predicting treatment response, prognosis and real-time ...
Ying Wang, Yanxia Liu, Zhiyun Zhang, Baohua Lu, Yuan Gao, Li Tong, Mingming Hu, Peter Ping Lin, Baolan Li, Tongmei Zhang   +9 more
doaj   +2 more sources

Novel approaches in cancer management with circulating tumor cell clusters [PDF]

Journal of Science: Advanced Materials and Devices, 2019
Tumor metastasis is responsible for the vast majority of cancer-associated morbidities and mortalities. Recent studies have disclosed the higher metastatic potential of circulating tumor cell (CTC) clusters than single CTCs.
Peyman Rostami, Navid Kashaninejad, Khashayar Moshksayan, Mohammad Said Saidi, Bahar Firoozabadi, Nam-Trung Nguyen   +5 more
doaj   +2 more sources

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry [PDF]

Scientific Reports, 2017
Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from blood ...
Sam H. Au, Jon Edd, Amy E. Stoddard, Keith H. K. Wong, Fabio Fachin, Shyamala Maheswaran, Daniel A. Haber, Shannon L. Stott, Ravi Kapur, Mehmet Toner   +9 more
doaj   +2 more sources

c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis

Biological Procedures Online
Background Circulating tumor cells (CTCs) serve as the “seeds” of tumor metastasis, and the clustering of CTCs is critically associated with tumor metastasis and the mortality of lung cancer patients.
Zhipeng Zhang, Xinyi Lu, Jianhui Tian, Jiaxuan Li, Shihui Liu, Jiajun Liu, Bin Luo, Jialiang Yao, Yao Liu, Yanhong Wang, Wang Yao, Yun Yang, Wenji Shangguan, Zujun Que   +13 more
doaj   +2 more sources

Circulating tumor cells clusters and their role in Breast cancer metastasis; a review of literature

Discover Oncology
Breast cancer is a significant and deadly threat to women globally. Moreover, Breast cancer metastasis is a complicated process involving multiple biological stages, which is considered a substantial cause of death, where cancer cells spread from the ...
Zeinab S. Sayed, Mohamed G. Khattap, Mostafa A. Madkour, Noha S. Yasen, Hanan A. Elbary, Reem A. Elsayed, Dalia A. Abdelkawy, Al-Hassan Soliman Wadan, Islam Omar, Mohamed H. Nafady   +9 more
doaj   +2 more sources

Targeting the CRYAB/β-Catenin Axis with an MMP-9-Responsive Hydrogel Disrupts CTC Clusters to Suppress Progression of Hepatocellular Carcinoma after Radiofrequency Ablation. [PDF]

Adv Sci (Weinh)
The graphical abstract illustrates that sublethal thermal stress after iRFA upregulates the chaperone CRYAB in residual HCC cells, which stabilizes β‐catenin and drives a dual pathological program, including EMT and N2‐TAN polarization, thereby leading to heterotypic CTC cluster formation. The MMP‐9‐responsive hydrogel (XB@Gel) delivers XAV‐939 and BMS‐
Chen H, Yang D, Pi S, Liu Y, Huang H, Ye F, Lin Y, Su Z, Huang Y.   +8 more
europepmc   +2 more sources

The Presence of Circulating Tumor Cell Cluster Characterizes an Aggressive Hepatocellular Carcinoma Subtype

Frontiers in Oncology, 2021
BackgroundGrowing evidence suggests that circulating tumor cell (CTC) clusters may be an important factor in the metastatic process, but their role in hepatocellular carcinoma (HCC) remains unclear.
Jing-Jing Yu, Chang Shu, Hui-Yuan Yang, Zhao Huang, Ya-Ni Li, Ran Tao, Yue-Yue Chen, Qian Chen, Xiao-Ping Chen, Wei Xiao   +9 more
doaj   +1 more source

Detection of CTC Clusters and a Dedifferentiated RNA-Expression Survival Signature in Prostate Cancer. [PDF]

Adv Sci (Weinh), 2019
Rates of progression and treatment response in advanced prostate cancer are highly variable, necessitating nonâ invasive methods to assess the molecular characteristics of these tumors in real time. The unique potential of circulating tumor cells (CTCs)
Kozminsky M, Fouladdel S, Chung JS, Wang Y, Smith DC, Alva A, Azizi E, Morgan T, Nagrath S.   +8 more
europepmc   +2 more sources

Circulating Tumor-Cell-Associated White Blood Cell Clusters in Peripheral Blood Indicate Poor Prognosis in Patients With Hepatocellular Carcinoma

Frontiers in Oncology, 2020
Aim: Circulating tumor cells (CTC) are a precursor to metastasis in several types of cancer and are occasionally found in the bloodstream in association with immune cells, such as white blood cells (WBCs).
Qiong Luo, Qiong Luo, Chunming Wang, Bangjian Peng, Xiaoyu Pu, Lei Cai, Hangyu Liao, Kunling Chen, Cheng Zhang, Yuan Cheng, Mingxin Pan   +10 more
doaj   +1 more source

Epithelial-Mesenchymal-Transition-Like Circulating Tumor Cell-Associated White Blood Cell Clusters as a Prognostic Biomarker in HR-Positive/HER2-Negative Metastatic Breast Cancer

Frontiers in Oncology, 2021
BackgroundAlthough positive Circulating tumor cells (CTCs) status has been validated as a prognostic marker in breast cancer, the interaction between immune cells and CTCs during the progress of Epithelial-mesenchymal-transition (EMT), and the clinical ...
Xiuwen Guan, Chunxiao Li, Yiqun Li, Jiani Wang, Zongbi Yi, Binliang Liu, Hongyan Chen, Jiasen Xu, Haili Qian, Binghe Xu, Binghe Xu, Fei Ma, Fei Ma   +12 more
doaj   +1 more source