Results 41 to 50 of about 6,850,236 (255)

A Dual‐Filtration System for Single‐Cell Sequencing of Circulating Tumor Cells and Clusters in HCC [PDF]

Hepatology Communications, 2022
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Identification and sequencing of circulating tumor (CT) cells and clusters may allow for noninvasive molecular characterization of HCC, which is an unmet need, as many patients with HCC do not undergo biopsy.
Vincent L. Chen, Qianhui Huang, Ramdane Harouaka, Yuheng Du, Anna S. Lok, Neehar D. Parikh, Lana X. Garmire, Max S. Wicha   +7 more
openaire   +3 more sources

Perspective on Circulating Tumor Cell Clusters: Why It Takes a Village to Metastasize [PDF]

Cancer Research, 2018
Abstract Circulating tumor cell (CTC) clusters may represent one of the key mechanisms initiating the metastasis process. However, the series of pathophysiologic events by which CTC clusters originate, enter the circulation, and reach the distant sites remain to be identified.
Giuliano M., Shaikh A., Lo H. C., Arpino G., De Placido S., Zhang X. H., Cristofanilli M., Schiff R., Trivedi M. V.   +8 more
openaire   +3 more sources

Circulating tumor biomarkers in early-stage breast cancer: characteristics, detection, and clinical developments

Frontiers in Oncology, 2023
Breast cancer is the most common form of cancer in women, contributing to high rates of morbidity and mortality owing to the ability of these tumors to metastasize via the vascular system even in the early stages of progression. While ultrasonography and
Jie Qiu, Da Qian, Yuancong Jiang, Liwei Meng, Liming Huang   +4 more
doaj   +1 more source

A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Oncology Letters, 2016
Metastasis is the major cause of mortality in patients with malignancies; however, the mechanisms of tumor cell dissemination and metastasis formation are obscure. Circulating tumor cells (CTCs) are believed to be a critical step for distant metastasis and are associated with a poor patient prognosis.
Yupeng, Hong, Ziduo, Li, Qi, Zhang
openaire   +3 more sources

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

A microfluidic device for label-free, physical capture of circulating tumor cell clusters. [PDF]

Nat Methods, 2015
Cancer cells metastasize through the bloodstream either as single migratory circulating tumor cells (CTCs) or as multicellular groupings (CTC clusters). Existing technologies for CTC enrichment are designed to isolate single CTCs, and although CTC clusters are detectable in some cases, their true prevalence and significance remain to be determined ...
Sarioglu AF, Aceto N, Kojic N, Donaldson MC, Zeinali M, Hamza B, Engstrom A, Zhu H, Sundaresan TK, Miyamoto DT, Luo X, Bardia A, Wittner BS, Ramaswamy S, Shioda T, Ting DT, Stott SL, Kapur R, Maheswaran S, Haber DA, Toner M.   +20 more
europepmc   +7 more sources

Liquid Biopsy: Detection of Circulating Tumor Cells in Esophageal Squamous Cell Carcinoma

, 2020
Circulating tumor cells (CTC) harvested in the blood of patients with esophageal squamous cell carcinoma (ESCC) are associated with certain clinical pathological parameters as well as patients’ prognosis and response to chemoradiation.
Lam, AK, Hamid, FB, Faysal Bin Hamid, Vinod Gopalan, Gopalan, V, Alfred K. Lam   +5 more
core   +1 more source

Detection of circulating tumour cell clusters in human glioblastoma [PDF]

British Journal of Cancer, 2018
Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularised malignant brain cancer. Individual circulating tumour cells (CTCs) are sporadically found in GBM patients, yet it is unclear whether multicellular CTC clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier.
Krol, Ilona, Castro-Giner, Francesc, Maurer, Martina, Gkountela, Sofia, Szczerba, Barbara, Scherrer, Ramona, Coleman, Niamh, Carreira, Suzanne, Bachmann, Felix, Anderson, Stephanie, Engelhardt, Marc, Lane, Heidi, Evans, Thomas Ronald Jeffrey, Plummer, Ruth, Kristeleit, Rebecca, Lopez, Juanita, Aceto, Nicola   +16 more
openaire   +7 more sources

A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation

Frontiers in Oncology, 2021
Metastasis is a multistep process in which cells must detach, migrate/invade local structures, intravasate, circulate, extravasate, and colonize. A full understanding of the complexity of this process has been limited by the lack of ability to study ...
Tyler A. Allen, Mark M. Cullen, Nathan Hawkey, Hiroyuki Mochizuki, Lan Nguyen, Elyse Schechter, Luke Borst, Jeffrey A. Yoder, Jennifer A. Freedman, Jennifer A. Freedman, Steven R. Patierno, Steven R. Patierno, Ke Cheng, Ke Cheng, William C. Eward, Jason A. Somarelli, Jason A. Somarelli   +16 more
doaj   +1 more source

Size-based detection of sarcoma circulating tumor cells and cell clusters

Oncotarget, 2017
Metastatic disease is the most important factor in determining the survival of sarcoma patients. Since sarcoma metastasis is predominantly hematogenous, we hypothesized that detection and quantification of circulating tumor cells (CTCs) could reflect response to therapy and risk of metastatic relapse.
Hayashi, Masanori, Zhu, Peixuan, McCarty, Gregory, Meyer, Christian F., Pratilas, Christine A., Levin, Adam, Morris, Carol D., Albert, Catherine M., Jackson, Kyle W., Tang, Cha-Mei, Loeb, David M.   +10 more
openaire   +3 more sources