Results 61 to 70 of about 6,850,236 (255)

Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells—Letter [PDF]

Cancer Research, 2016
Blood-borne spread is responsible for the vast majority of cancer-related deaths, and it is recognized that clusters of circulating tumor cells (CTC) are much more likely to cause metastasis than single CTCs.
Garona, Juan, Alonso, Daniel Fernando
openaire   +3 more sources

A narrative review of circulating tumor cells clusters: A key morphology of cancer cells in circulation promote hematogenous metastasis

Frontiers in Oncology, 2022
Circulating tumor cells (CTCs) that survive in the blood are playing an important role in the metastasis process of tumor. In addition, they have become a tool for tumor diagnosis, prognosis and recurrence monitoring. CTCs can exist in the blood as individual cells or as clumps of aggregated cells. In recent years, more and more studies have shown that
Qiong Chen, Jueyao Zou, Yong He, Yanhong Pan, Yanhong Pan, Gejun Yang, Han Zhao, Ying Huang, Yang Zhao, Yang Zhao, Aiyun Wang, Aiyun Wang, Wenxing Chen, Wenxing Chen, Yin Lu, Yin Lu   +15 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gap junctions contribute to anchorage-independent clustering of breast cancer cells

BMC Cancer, 2018
Background Cancer cell aggregation is a key process involved in the formation of clusters of circulating tumor cells. We previously reported that cell-cell adhesion proteins, such as E-cadherin, and desmosomal proteins are involved in cell aggregation to
Fabien Gava, Lise Rigal, Odile Mondesert, Elise Pesce, Bernard Ducommun, Valérie Lobjois   +5 more
doaj   +1 more source

Capture of circulating tumour cell clusters using straight microfluidic chips

, 2019
Circulating tumour cells (CTCs) are the metastatic precursors to distant disease in head and neck cancers (HNCs). Whilst the prognostic and predictive value of single CTCs have been well documented, the role of CTC clusters, which potentially have a ...
Zhou, Jian, Chamindie Punyadeera, Kenny, Liz, Punyadeera, Chamindie, Kulasinghe, Arutha, Jian Zhou, Liz Kenny, Papautsky, Ian, Ian Papautsky, Arutha Kulasinghe   +9 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Additional file 9: of Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

, 2018
Table S7. Clinical features of patients with single circulating tumor cell and circulating tumor cell clusters. The table shows clinical features of patients in whom only single circulating tumor cells (CTC single cell) or also clustered circulating ...
Viola Heinzelmann-Schwarz (390410), Barbara Szczerba (5997695), Walter Weber (5997716), Christoph Rochlitz (190083), Ramona Scherrer (5997704), Christian Kurzeder (5997713), Marcus Vetter (3422660), Alfred Zippelius (805066), Ilona Krol (5997701), Julia Landin (5997692), Cinzia Donato (5997698), Alexandra Malinovska (5997710), Sofia Gkountela (191896), Francesc Castro-Giner (5659600), Catharina Balmelli (5997707), Nicola Aceto (5997719)   +15 more
core   +1 more source

Modulation of Early Neutrophil Granulation: The Circulating Tumor Cell-Extravesicular Connection in Pancreatic Ductal Adenocarcinoma

, 2021
Tumor cells dissociate from the primary site and enter into systemic circulation (circulating tumor cells, CTCs) either alone or as tumor microemboli (clusters); the latter having an increased predisposition towards forming distal metastases than single ...
Vaish, Utpreksha, Sundaram, Ramakrishnan, Ramakrishnan Sundaram, Charles Jacob, Harrys Kishore, Lavania, Shweta, Tyler Kashuv, Melinda Boone, Harrys Charles Jacob, Vikas Dudeja, Shweta Lavania, Signorelli, Rossana, Charles Richard, John Lalith, Saluja, Ashok Kumar, Rossana Signorelli, Dudeja, Vikas, John Charles Richard, Ashley Middleton, Utpreksha Vaish, Ranjitha Boopathy, Ashok Saluja, Middleton, Ashley, Boone, Melinda Minucci, Kashuv, Tyler, Boopathy, Ranjitha   +23 more
core   +1 more source

Capturing, creating, and characterizing circulating tumor cells and clusters

Scilight, 2022
Microfluidic devices can aid in developing in vitro models and pave the way for liquid biopsy as a minimally invasive method for disease monitoring.
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source