Results 51 to 60 of about 6,850,236 (255)

Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction

iScience, 2022
Summary: Small-cell lung cancer (SCLC) methylome is understudied. Here, we comprehensively profile SCLC using cell-free methylated DNA immunoprecipitation followed by sequencing (cfMeDIP-seq).
Sami Ul Haq, Sabine Schmid, Mansi K. Aparnathi, Katrina Hueniken, Luna Jia Zhan, Danielle Sacdalan, Janice J.N. Li, Nicholas Meti, Devalben Patel, Dangxiao Cheng, Vivek Philip, Ming S. Tsao, Michael Cabanero, Daniel de Carvalho, Geoffrey Liu, Scott V. Bratman, Benjamin H. Lok   +16 more
doaj   +1 more source

Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]

, 1967
In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Okada, Shigeru, Grace, James T., Hayashi, Kenj, Kimoto, Tetsuo, Sogabe, Koichi, Shigehisa, Morio   +5 more
core   +1 more source

Detection of Tumor Cell-Specific mRNA in the Peripheral Blood of Patients with Breast Cancer-Evaluation of Several Markers with Real-Time Reverse Transcription-PCR [PDF]

, 2013
It is widely known that cells from epithelial tumors, e. g., breast cancer, detach from their primary tissue and enter blood circulation. We show that the presence of circulating tumor cells (CTCs) in samples of patients with primary and metastatic ...
Simone Hofmann, Kölbl, Alexandra C., Jeschke, Udo, Klaus Friese, Andergassen, Ulrich, Neugebauer, Julia, Alexandra Kölbl, Udo Jeschke, Matthias Ilmer, Julia Neugebauer, Ilmer, Matthias, Ulrich Andergassen, Engelstädter, Verena, Schindlbeck, Christian, Hofmann, Simone, Hutter, Stefan, Stefan Hutter, Ra C. Kölbl, Friese, Klaus, Verena Engelstädter, Christian Schindlbeck   +20 more
core   +1 more source

The functional and clinical roles of liquid biopsy in patient-derived models

Journal of Hematology & Oncology, 2023
The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) and extracellular vesicles (EVs) in the patient's body fluid.
Ziqing Zhu, Erya Hu, Hong Shen, Jun Tan, Shan Zeng   +4 more
doaj   +1 more source

Identification of fibroblast-related genes based on single-cell and machine learning to predict the prognosis and endocrine metabolism of pancreatic cancer

Frontiers in Endocrinology, 2023
BackgroundSingle-cell sequencing technology has become an indispensable tool in tumor mechanism and heterogeneity studies. Pancreatic adenocarcinoma (PAAD) lacks early specific symptoms, and comprehensive bioinformatics analysis for PAAD contributes to ...
Yinghua Xu, Xionghuan Chen, Xionghuan Chen, Nan Liu, Zhong Chu, Qiang Wang   +5 more
doaj   +1 more source

The Prognostic Significance of Circulating Tumor Cells in Patients with Pancreatobiliary Cancer

, 2023
Background: Circulating tumor cells are cancer cells which separate from the primary tumor and enter systemic circulation. In this study, it was aimed to examine the relationship between circulating tumor cells isolated and identified from the peripheral
Başbınar, Yasemin, Öztop, İlhan, Tarkan Ünek, Uysal, Tuğba, İbrahim Astarcıoğlu, Asim Leblebici, Ünek, İlkay Tuğba, Leblebici, Asım, Hülya Ellidokuz, İlhan Öztop, Tuğba Uysal, Anıl Aysal, Ellidokuz, Hülya, Ibrahim Astarcioglu, Astarcıoğlu, İbrahim, Sağol, Özgül, İlkay Tuğba Ünek, Aysal, ANIL, Anil Aysal, Ece Çakıroğlu, Asım Leblebici, Yaemin Baspinar, Caner Karaca, Yasemin Başbınar, Çakıroğlu, Ece, Karaca, Caner, Ece Cakiroglu, Özgül Sağol, Ünek, Tarkan   +28 more
core   +1 more source

Proportion of circulating tumor cell clusters increases during cancer metastasis [PDF]

Cytometry Part A, 2016
AbstractCirculating tumor cell (CTC) clusters are found among CTCs and show significantly greater potential for an important role in cancer metastasis than single CTCs, which have been traditionally believed as the majority of CTCs. The accurate proportion and dynamics of CTC clusters remain unclear due to the fact that CTCs in blood flow are very ...
Yuanzhen, Suo, Chengying, Xie, Xi, Zhu, Zhichao, Fan, Zhangru, Yang, Hao, He, Xunbin, Wei   +6 more
openaire   +2 more sources

A growing entourage for heterotypic circulating tumor cell clusters

Trends in Cancer
Circulating tumor cell (CTC) clusters have emerged as key mediators of cancer spread. Among these, heterotypic CTC clusters exemplify how cooperative interactions between different cell types may enhance metastasis efficiency. Recent studies by Scholten et al. and Schuster et al. uncover additional immune cell partners, including T cells and monocytes,
Gvozdenovic, Ana, Aceto, Nicola
openaire   +2 more sources

Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells [PDF]

Cancer Research, 2015
Abstract Clusters of circulating tumor cells (CTC) exhibit more robust metastatic properties than single CTC. Thus, understanding the distinct behaviors of CTC clusters and how CTC clustering is regulated may offer new insights into how to limit metastasis.
Jin Woo, Choi, Jun Ki, Kim, Yun Jung, Yang, Pilhan, Kim, Kwon-Ha, Yoon, Seok Hyun, Yun   +5 more
openaire   +2 more sources

Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.

, 2022
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation.
Peng, Xinxia, Asad, Dana, Dinh, Phuong-Uyen, Cheng, Ke, Hensley, M Taylor, Cores, Jhon, Campbell, Connor, Vandergriff, Adam, Qiao, Li, Hu, Shiqi, Allen, Tyler A, Shen, Deliang, Liang, Hongxia, Amu, Emmanuel, Yoder, Jeffrey A, Su, Teng, Harrell, Erin, Tang, Junnan, Shive, Heather   +18 more
core   +1 more source