Results 41 to 50 of about 186,683 (292)

Can Liquid Biopsy Cancer Research Offering Personalized Cancer Treatment in Gynecology be a Realistic Expectation?

Clinical and Experimental Obstetrics & Gynecology, 2023
This paper encourages understanding a non-invasive technology—the “Liquid biopsy”, including circulating tumor cells (CTCs) and circulating tumor DNA (ct DNA) technology, that can help diagnose early cancers, cancer relapse, and resistance to ...
Felix Wong, Bee Luan Khoo, Karen Kar Loen Chan   +2 more
doaj   +1 more source

Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Nature Communications, 2021
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is ...
Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup   +19 more
doaj   +1 more source

Nucleosomes in serum as a marker for cell death [PDF]

, 2001
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Holdenrieder, Stefan, Dietrich Seidel, Seidel, Dietrich, Michael Untch, Fertig, Georg, Stieber, Petra, Fürst, Heinrich, Georg Fertig, Nikolaus Schmeller, Heinz Bodenmüller, Stefan Holdenrieder, Schmeller, Nikolaus, Heinrich Fürst, Bodenmüller, Heinz, Untch, Michael, Petra Stieber   +15 more
core   +1 more source

Accurate detection of circulating tumor DNA using nanopore consensus sequencing [PDF]

, 2021
Levels of circulating tumor DNA (ctDNA) in liquid biopsies may serve as a sensitive biomarker for real-time, minimally-invasive tumor diagnostics and monitoring.
van Ginkel, Joost H., Kloosterman, Wigard P., Peltenburg, Boris, Devriese, Lot A, de Ridder, Jeroen, de Bree, Remco, van Ginkel, Joost H, Chen, Li-Ting, Devriese, Lot A., Willems, Stefan M, Kloosterman, Wigard P, Willems, Stefan M., Renkens, Ivo, Straver, Roy, Terhaard, Chris, Marcozzi, Alessio, Chen, Li Ting, Jager, Myrthe, Elferink, Martin, van Kuik, Joyce   +19 more
core   +1 more source

Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer [PDF]

, 2019
Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck
Anders Ståhlberg, Saunders, Stefanie, Tony E. Godfrey, Irina Kalatskaya, Krzyzanowski, Paul M, Anand Devaiah, Paul M. Krzyzanowski, Stefanie Saunders, Ståhlberg, Anders,, Devaiah, Anand, Filges, Stefan,, Jalisi, Scharukh, Stein, Lincoln D, Sridhar, Praveen, Godfrey, Tony E, Egyud, Matthew, Jiao, Wei, Lincoln D. Stein, Stefan Filges, Scharukh Jalisi, Matthew Egyud, Yamada, Emiko, Praveen Sridhar, Emiko Yamada, Wei Jiao, Kalatskaya, Irina   +25 more
core   +1 more source

Circulating tumor DNA – from biology to potential clinical applications in diffuse large B-cell lymphomas [PDF]

During the last 20 years, significant progress has been made in understanding the biology of cancer cells. Assessment of the molecular profile of neoplastic cells collected by tissue biopsy using next-generation sequencing techniques makes it possible to
Kinga Gwóźdź-Bąk, Krzysztof Lewandowski   +1 more
core   +1 more source

Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring

Oncology Research, 2023
Liquid biopsy, including both circulating tumor cells and circulating tumor DNA, is becoming more popular as a diagnostic tool in the clinical management of breast cancer. Elevated concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and ...
ALEMZADEH, EFFAT, ALLAHQOLI, LEILA, DEHGHAN, HAMIDEH, MAZIDIMORADI, AFROOZ, GHASEMPOUR, ALIREZA, SALEHINIYA, HAMID   +5 more
openaire   +2 more sources

Circulating tumor DNA related to tumor dynamics in cervical cancer patients. [PDF]

, 2012
Circulating tumor DNA related to tumor dynamics in cervical cancer patients.
Emmanuelle Lappartient (140028), Virginie Fourchotte (140038), Anne de la Rochefordière (140034), Jean-Yves Pierga (29242), Stéphanie Saada (140031), Emmanuelle Jeannot (140022), Maura Campitelli (140015), Martine Peter (140025), Peter Petrow (631), Xavier Sastre-Garau (29244), Séverine Alran (140041), Jérôme Couturier (81165), Paul Cottu (140044), Olivier Lantz (46680)   +13 more
core   +1 more source

Prospective assessment of circulating tumor DNA in patients with metastatic uveal melanoma treated with tebentafusp

Nature Communications
Tebentafusp, a bispecific immune therapy, is the only drug that demonstrated an overall survival benefit in patients with metastatic uveal melanoma (MUM).
Manuel Rodrigues, Toulsie Ramtohul, Aurore Rampanou, José Luis Sandoval, Alexandre Houy, Vincent Servois, Léah Mailly-Giacchetti, Gaelle Pierron, Anne Vincent-Salomon, Nathalie Cassoux, Pascale Mariani, Caroline Dutriaux, Marc Pracht, Thomas Ryckewaert, Jean-Emmanuel Kurtz, Sergio Roman-Roman, Sophie Piperno-Neumann, François-Clément Bidard, Marc-Henri Stern, Shufang Renault   +19 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source