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Circulating DNA and Survival in Solid Tumors [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2016 Abstract Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict ...
Ocaña A +11 more
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, 2022 Analysis of cell-free circulating tumor DNA obtained by liquid biopsy is a non-invasive approach that may provide clinically actionable information when conventional tissue biopsy is inaccessible or infeasible.
Liu, Li +31 more
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Monitor tumor burden with circulating tumor DNA [PDF]
Cancer Biology & Therapy, 2013 There is a need to identify better biomarkers to monitor diseases and/or assess therapeutic responses. For those with cancer, one can identify DNA fragments that contain somatic mutations originating in the tumor DNA in plasma or serum. There have been several early studies suggesting that advances in sequencing technologies will allow identification ...
William D, Figg, Jim, Reid
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Circulating Tumor DNA in Oncology [PDF]
Processes, 2021 When somatic cells in the human body undergo apoptosis or necrosis, the released DNA enters the bloodstream. This type of DNA is called cell-free DNA (cfDNA). In patients with cancer, DNA released from tumor cells is called circulating tumor DNA (ctDNA), which carries genetic alterations specific to tumor cells.
Saeko Sakaeda, Yoichi Naito
openaire +1 more source
Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs [PDF]
, 2017 Circulating nucleic acids (CNAs), for example, circulating tumor DNA (ctDNA) and circulating microRNA (miRNA), represent promising biomarkers in several diseases including cancer.
CIACCIO, Marcello +11 more
core +1 more source
Circulating tumor DNA in Hodgkin lymphoma
Annals of Hematology, 2022 Abstract Somatic mutations of genes involved in NF-κB, PI3K/AKT, NOTCH, and JAK/STAT signaling pathways play an important role in the pathogenesis of Hodgkin lymphoma (HL). HL tumor cells form only about 5% of the tumor mass; however, it was shown that HL tumor-derived DNA could be detected in the bloodstream.
Maria Maco +6 more
openaire +2 more sources
Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]
, 1967 In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Okada, Shigeru +5 more
core +1 more source
ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress
Computational and Structural Biotechnology Journal, 2018 We discuss the current status of liquid biopsy and its advantages and challenges with a focus on pre-analytical sample handling, technologies and workflows. The potential of circulating tumor cells and circulating tumor DNA is pointed out and an overview
Martin H.D. Neumann +3 more
doaj +1 more source
Clinical correlates of circulating cell-free DNA tumor fraction.
PLoS ONE, 2021 BackgroundOncology applications of cell-free DNA analysis are often limited by the amount of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a blood sample.
Joerg Bredno +4 more
doaj +1 more source
Circulating tumor DNA as prognostic markers for late stage NSCLC with bone metastasis
The International Journal of Biological Markers, 2018 Purpose: Bone metastases from non-small cell lung cancer (NSCLC) are common, and current prognostic stratification methods are challenging to predict outcomes.
Jiguang Jia +3 more
doaj +1 more source