Results 21 to 30 of about 185,596 (291)
A fatal affair: Circulating tumor cell relationships that shape metastasis
iScience, 2021 Summary: Circulating tumor cells are metastatic precursors in several cancer types. Their biology and clinical utility are subject to numerous investigations, yet one aspect that is often neglected is their entanglement with the tumor microenvironment ...
Lauren L. Ozimski +2 more
doaj +1 more source
Circulating DNA and Survival in Solid Tumors [PDF]
Cancer Epidemiology, Biomarkers & Prevention, 2016 Abstract Background: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict ...
Ocaña A +11 more
openaire +4 more sources
Translational Oncology, 2023 Background: Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring.
Eva Kristine Ruud Kjær +4 more
doaj +1 more source
The Role of Liquid Biopsy Analytes in Diagnosis, Treatment and Prognosis of Colorectal Cancer
Frontiers in Endocrinology, 2022 Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract worldwide and is a serious threat to human life and health. CRC occurs and develops in a multi-step, multi-stage, and multi-gene process, in which abnormal gene ...
JinHua He +8 more
doaj +1 more source
Tumor Biology, 2020 Detection of circulating tumor DNA is a new noninvasive technique with potential roles in diagnostic, follow-up, and prognostic evaluation of patients with many types of solid tumors.
Mariana Cartaxo Alves +8 more
doaj +1 more source
Monitor tumor burden with circulating tumor DNA [PDF]
Cancer Biology & Therapy, 2013 There is a need to identify better biomarkers to monitor diseases and/or assess therapeutic responses. For those with cancer, one can identify DNA fragments that contain somatic mutations originating in the tumor DNA in plasma or serum. There have been several early studies suggesting that advances in sequencing technologies will allow identification ...
William D, Figg, Jim, Reid
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Circulating tumor DNA in Hodgkin lymphoma
Annals of Hematology, 2022 Abstract Somatic mutations of genes involved in NF-κB, PI3K/AKT, NOTCH, and JAK/STAT signaling pathways play an important role in the pathogenesis of Hodgkin lymphoma (HL). HL tumor cells form only about 5% of the tumor mass; however, it was shown that HL tumor-derived DNA could be detected in the bloodstream.
Maria Maco +6 more
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Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs [PDF]
, 2017 Circulating nucleic acids (CNAs), for example, circulating tumor DNA (ctDNA) and circulating microRNA (miRNA), represent promising biomarkers in several diseases including cancer.
CIACCIO, Marcello +11 more
core +1 more source
ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress
Computational and Structural Biotechnology Journal, 2018 We discuss the current status of liquid biopsy and its advantages and challenges with a focus on pre-analytical sample handling, technologies and workflows. The potential of circulating tumor cells and circulating tumor DNA is pointed out and an overview
Martin H.D. Neumann +3 more
doaj +1 more source
The Role of Circulating Tumor DNA Analyses
, 2022 All cells shed DNA into circulation (cell-free DNA; cfDNA) based on various processes like apoptosis, necrosis, or active release (Stroun et al., Clin Chim Acta 313(1–2):139–142, 2001; Schwarzenbach et al., Nat Rev Cancer 11(6):426–437, 2011). A fraction of the cfDNA may be circulating tumor DNA (ctDNA) that represents the DNA released from cancer ...
Christensen, Emil +2 more
openaire +1 more source