Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells [PDF]
, 2017 Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in ...
Austin, Laura +9 more
core +3 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 This paper encourages understanding a non-invasive technology—the “Liquid biopsy”, including circulating tumor cells (CTCs) and circulating tumor DNA (ct DNA) technology, that can help diagnose early cancers, cancer relapse, and resistance to ...
Felix Wong +2 more
doaj +1 more source
Limited utility of qPCR-based detection of tumor-specific circulating mRNAs in whole blood from clear cell renal cell carcinoma patients [PDF]
, 2020 BACKGROUND: RNA sequencing data is providing abundant information about the levels of dysregulation of genes in various tumors. These data, as well as data based on older microarray technologies have enabled the identification of many genes which are ...
Busch, Jonas +6 more
core +2 more sources
What information could the main actors of liquid biopsy provide? A representative case of non-small cell lung cancer (NSCLC) [PDF]
, 2018 In non-small cell lung cancer (NSCLC), there is a consensus regarding the use of liquid biopsy, generally, to detect "druggable" mutations and, in particular, to monitor tyrosine kinase inhibitor (TKI) treatments. However, whether circulating tumor cells
Manicone, M. +6 more
core +1 more source
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
Nature Communications, 2021 Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is ...
Guanhua Zhu +19 more
doaj +1 more source
Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer [PDF]
Chonnam Medical Journal, 2016 Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the long process of cancer metastasis. As a 'liquid biopsy', CTC molecular examination and investigation of single cancer cells create an important opportunity for providing
Nurwidya, Fariz +6 more
openaire +2 more sources
Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology. [PDF]
, 2017 There has been increased interest in utilizing non-invasive "liquid biopsies" to identify biomarkers for cancer prognosis and monitoring, and to isolate genetic material that can predict response to targeted therapies. Circulating tumor cells (CTCs) have
Che, James +12 more
core +1 more source
Liquid Biopsies: Genotyping Circulating Tumor DNA
Journal of Clinical Oncology, 2014 Genotyping tumor tissue in search of somatic genetic alterations for actionable information has become routine practice in clinical oncology. Although these sequence alterations are highly informative, sampling tumor tissue has significant inherent limitations; tumor tissue is a single snapshot in time, is subject to selection bias resulting from ...
L. A. Diaz, BARDELLI, Alberto
openaire +4 more sources
Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer
Journal of Ovarian Research, 2017 Limited understanding of ovarian cancer (OC) genome portrait has hindered the therapeutic advances. The serial monitoring of tumor genotypes is becoming increasingly attainable with circulating cell-free DNA (cf-DNA) and circulating tumor cells (CTCs ...
Xianliang Cheng +3 more
doaj +1 more source