Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples [PDF]
, 2012 Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging ...
John Smith +6 more
core +1 more source
Specific antigen of tumor cell transformed by DNA extracted from SV-40 virus [PDF]
, 1967 In the immunofluorescent study it has been revealed that rabbit sera immunized with transformed cells induced by SV-40 DNA, produce circulating antibody capable of re:lcting with intranuclear antigens synthesized by SV-40 complyte virus transforming ...
Okada, Shigeru +5 more
core +1 more source
ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress
Computational and Structural Biotechnology Journal, 2018 We discuss the current status of liquid biopsy and its advantages and challenges with a focus on pre-analytical sample handling, technologies and workflows. The potential of circulating tumor cells and circulating tumor DNA is pointed out and an overview
Martin H.D. Neumann +3 more
doaj +1 more source
The Role of Circulating Tumor DNA Analyses
, 2022 All cells shed DNA into circulation (cell-free DNA; cfDNA) based on various processes like apoptosis, necrosis, or active release (Stroun et al., Clin Chim Acta 313(1–2):139–142, 2001; Schwarzenbach et al., Nat Rev Cancer 11(6):426–437, 2011). A fraction of the cfDNA may be circulating tumor DNA (ctDNA) that represents the DNA released from cancer ...
Christensen, Emil +2 more
openaire +1 more source
The importance of circulating tumor products as „liquid biopsies” in colorectal cancer
Journal of Mind and Medical Sciences, 2018 Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Alina Miscoci +6 more
doaj +1 more source
Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA [PDF]
Cancer Discovery, 2014 Abstract The ability to study nonhematologic cancers through noninvasive sampling of blood is one of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven both by major technologic advances, including the isolation of intact cancer cells and the analysis of cancer cell–derived DNA from blood samples ...
Daniel A, Haber, Victor E, Velculescu
openaire +2 more sources
Tumor Heterogeneity in Hepatocellular Carcinoma: Facing the Challenges [PDF]
, 2017 Tumor heterogeneity in hepatocellular carcinoma (HCC), such as that found in second primary tumors after curative treatment, synchronous multifocal tumors of different clonality, or intratumor heterogeneity, poses severe challenges for the development ...
鄭安理;徐志宏;許駿;呂理駿 +1 more
core +1 more source
Potential of circulating tumor DNA to refine immunotherapy [PDF]
, 2023 Circulating tumor DNA (ctDNA) is a noninvasive strategy to disease assessment of minimal residual disease and treatment response for advanced cancer. ctDNA is emerging as a tool for use in clinical practice and informing novel clinical trial designs in ...
Luke, Jason J. +3 more
core +1 more source
Circulating Tumor DNA Mutation Profiling by Targeted Next Generation Sequencing Provides Guidance for Personalized Treatments in Multiple Cancer Types [PDF]
, 2017 Cancer is a disease of complex genetic alterations, and comprehensive genetic diagnosis is beneficial to match each patient to appropriate therapy. However, acquisition of representative tumor samples is invasive and sometimes impossible.
Chen, XF +16 more
core +1 more source
Characterization of cell-free circulating DNA in plasma in patients with prostate cancer [PDF]
, 2013 Cell-free circulating DNA in plasma and serum may serve as a biomarker for malignant tumor detection and follow up in patients with a variety of solid tumors including prostate cancer.
Gehrke, Flavia de Sousa +6 more
core +1 more source