Results 31 to 40 of about 185,596 (291)

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA [PDF]

Cancer Discovery, 2014
Abstract The ability to study nonhematologic cancers through noninvasive sampling of blood is one of the most exciting and rapidly advancing fields in cancer diagnostics. This has been driven both by major technologic advances, including the isolation of intact cancer cells and the analysis of cancer cell–derived DNA from blood samples ...
Daniel A, Haber, Victor E, Velculescu
openaire   +2 more sources

The importance of circulating tumor products as „liquid biopsies” in colorectal cancer

Journal of Mind and Medical Sciences, 2018
Liquid biopsies represent an array of plasma analysis tests that are studied to evaluate and identify circulating tumor products, especially circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA).
Alina Miscoci, Cristian D. Pirvu, Veronica Calborean, Costin T. Streba, Otilia C. Rogoveanu, Vlad Pădureanu, Cristin C. Vere   +6 more
doaj   +1 more source

Applications of Circulating Tumor Cells and Circulating Tumor DNA in Precision Oncology for Breast Cancers

, 2022
Liquid biopsies allow for the detection of cancer biomarkers such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Elevated levels of these biomarkers during cancer treatment could potentially serve as indicators of cancer progression
Singh, Balraj, Addanki, Sridevi, Vanessa Nicole Sarli, Lucci, Anthony, Sridevi Addanki, Balraj Singh, Anthony Lucci, Sarli, Vanessa Nicole, Salyna Meas, Meas, Salyna   +9 more
core   +1 more source

Can Liquid Biopsy Cancer Research Offering Personalized Cancer Treatment in Gynecology be a Realistic Expectation?

Clinical and Experimental Obstetrics & Gynecology, 2023
This paper encourages understanding a non-invasive technology—the “Liquid biopsy”, including circulating tumor cells (CTCs) and circulating tumor DNA (ct DNA) technology, that can help diagnose early cancers, cancer relapse, and resistance to ...
Felix Wong, Bee Luan Khoo, Karen Kar Loen Chan   +2 more
doaj   +1 more source

Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden

Nature Communications, 2021
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is ...
Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup   +19 more
doaj   +1 more source

Nucleosomes in serum as a marker for cell death [PDF]

, 2001
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Holdenrieder, Stefan, Dietrich Seidel, Seidel, Dietrich, Michael Untch, Fertig, Georg, Stieber, Petra, Fürst, Heinrich, Georg Fertig, Nikolaus Schmeller, Heinz Bodenmüller, Stefan Holdenrieder, Schmeller, Nikolaus, Heinrich Fürst, Bodenmüller, Heinz, Untch, Michael, Petra Stieber   +15 more
core   +1 more source

Accurate detection of circulating tumor DNA using nanopore consensus sequencing [PDF]

, 2021
Levels of circulating tumor DNA (ctDNA) in liquid biopsies may serve as a sensitive biomarker for real-time, minimally-invasive tumor diagnostics and monitoring.
van Ginkel, Joost H., Kloosterman, Wigard P., Peltenburg, Boris, Devriese, Lot A, de Ridder, Jeroen, de Bree, Remco, van Ginkel, Joost H, Chen, Li-Ting, Devriese, Lot A., Willems, Stefan M, Kloosterman, Wigard P, Willems, Stefan M., Renkens, Ivo, Straver, Roy, Terhaard, Chris, Marcozzi, Alessio, Chen, Li Ting, Jager, Myrthe, Elferink, Martin, van Kuik, Joyce   +19 more
core   +1 more source

Circulating tumor cells and circulating tumor DNA in breast cancer diagnosis and monitoring

Oncology Research, 2023
Liquid biopsy, including both circulating tumor cells and circulating tumor DNA, is becoming more popular as a diagnostic tool in the clinical management of breast cancer. Elevated concentrations of these biomarkers during cancer treatment may be used as markers for cancer progression as well as to understand the mechanisms underlying metastasis and ...
ALEMZADEH, EFFAT, ALLAHQOLI, LEILA, DEHGHAN, HAMIDEH, MAZIDIMORADI, AFROOZ, GHASEMPOUR, ALIREZA, SALEHINIYA, HAMID   +5 more
openaire   +2 more sources

Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients

, 2006
Introduction: Risk stratification of severely ill patients remains problematic, resulting in increased interest in potential circulating markers, such as cytokines, procalcitonin and brain natriuretic peptide. Recent reports have indicated the usefulness
Bennett, ED, Rhodes, A, Wort, SJ, Collinson, P, Thomas, H   +4 more
core   +1 more source

Comparison of KRAS Mutation Assessment in Tumor DNA and Circulating Free DNA in Plasma and Serum Samples

, 2012
Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging ...
John Smith, Marcia T. Eisenberg, Lauren Kam-Morgan, Shethah R. Morgan, Emma Donald, Eddie Kallam, Jessica Whiteley   +6 more
core   +1 more source