Results 101 to 110 of about 186,683 (292)
Circulating tumor DNA in advanced colorectal carcinoma patients [PDF]
, 2018 Colorectal carcinoma (CRC) is worldwide known as one of the most often tumor diseases. Approximately 50 % of patients are diagnosed with advanced stage of CRC and moreover even after removing all of the tumor bearings, there is high risk of its ...
Kopalová, Dominika
core
Circulating Tumor DNA and Tissue Testing for Pancreatobiliary Tumors
JAMA Network OpenImportanceThe prognosis of advanced pancreaticobiliary tumors is poor. Next-generation sequencing (NGS) of tissue samples is utilized to identify actionable alterations, but there are occasional limitations due to inadequate tissue acquisition. Circulating tumor DNA (ctDNA) is an alternative method, but its correlation with tissue-based NGS remains ...
Mahadevia, Himil +23 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Liquid Biopsy in Gastrointestinal Cancers
Diagnostics, 2018 Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor’s genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC’s) and circulating tumor ...
Aman Saini +7 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Circulating Tumor DNA: Measurement and Clinical Utility [PDF]
, 2018 Circulating tumor DNA (ctDNA) is a component of the “naked” DNA found in blood. It can be isolated from plasma and represents combined genetic material from the primary tumor and metastases.
Joshua Donaldson, Ben Ho Park
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
DNA methylation in follicular lymphoma [PDF]
, 2010 PhDFollicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival.
Ó Riain, Ciarán Liam
core
Cell-free DNA in the circulation as a non-invasive biomarker for breast cancer [PDF]
, 2013 Breast cancer remains the most common cancer among women worldwide. Although standard screening methods such as clinical breast examination (CBE) and Full-Field Digital Mammography (FFDM) are non-invasive itself, their sensitivity and specificity is ...
Kohler, Corina
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2018 Hepatocellular carcinoma (HCC) is a highly malignant disease with a poor prognosis and high mortality due to a low early diagnosis rate, resistance to systemic treatments and progression to late-stage liver disease.
Jie Li +6 more
doaj +1 more source