Results 101 to 110 of about 185,596 (291)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cell-free DNA in the circulation as a non-invasive biomarker for breast cancer [PDF]

, 2013
Breast cancer remains the most common cancer among women worldwide. Although standard screening methods such as clinical breast examination (CBE) and Full-Field Digital Mammography (FFDM) are non-invasive itself, their sensitivity and specificity is ...
Kohler, Corina
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Journal of Experimental & Clinical Cancer Research, 2018
Hepatocellular carcinoma (HCC) is a highly malignant disease with a poor prognosis and high mortality due to a low early diagnosis rate, resistance to systemic treatments and progression to late-stage liver disease.
Jie Li, Xu Han, Xiaona Yu, Zongzhen Xu, Guangsheng Yang, Bingqi Liu, Peng Xiu   +6 more
doaj   +1 more source

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes.

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability.
Xin Hu (38924), Yuanxin Xi (255031), Pedro Rocha (386032), Monique B Nilsson (18126607), Yael Raviv (18126616), Veronique Hofman (258841), John V Heymach (13586320), Mina Gaga (2938956), Bingnan Zhang (15161805), Paul Hofman (103032), Christine M Lovly (18126598), Edurne Arriola (632850), Jing Wang (6206297), Vasileios Panagoulias (18126613), Jianjun Zhang (220300), Marcos R Estecio (18126589), Hai Tran (470946), Kyle Concannon (15162981), Ignacio I Wistuba (18126622), Maria Gabriela Raso (14886905), Catherine A Schnabel (18126619), Peter Van Loo (9838), Azusa Tanimoto (14936243), Lixia Diao (184400), Natalie I Vokes (17808782), Adam Wasserstrom (27739), Whitney Elisabeth Lewis (18126604), Kimie Kondo (195898), Simon Heeke (8460396), Danny Frumkin (15144570), Prasad Kopparapu (524553), Ildikó Horváth (530804), Maarten Jansen (18126610), Qi Wang (22418), Benjamin B Morris (18126592), Allison Stewart (50114), Carl M Gay (18126586), Siqi Lai (18126595), Luana Guimaraes De Sousa (18126601), Aharona Shuali (15144567), Ximing Tang (253548), Lauren A Byers (17532391)   +41 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Circulating tumor DNA. Modern views about the possibility of use in uveal melanoma

Российский офтальмологический журнал
Choroidal melanoma is the most common and highly malignant intraocular tumor due to its tendency to hematogenous metastasis. In the vast majority of cases, the liver is affected.
A. M. Bogatyrev, E. E. Grishina, A. R. Zaretsky, P. I. Semenikhina   +3 more
doaj   +1 more source

From Somatic Variants Toward Precision Oncology: An Investigation of Reporting Practice for Next-Generation Sequencing-Based Circulating Tumor DNA Analysis

, 2019
Background: With the accelerated development of next-generation sequencing (NGS), identified variants, and targeted therapies, clinicians who confront the complicated and multifarious genetic information may not effectively incorporate NGS-based ...
Pillay, Nalishia, Tay, Kwang Hong, Zhou, Li, Peng, Rongxue, Horan, Martin P, Zhang, Rui, Li, Jinming, Badrick, Tony, Chai, Sze Yee   +8 more
core   +1 more source

Prevalence of Systemic Lupus Erythematosus in Australia, 2010–2022: A Population‐Based Study Using Linked National Administrative Health Data

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a heterogenous inflammatory condition with widely varying global prevalence estimates. The frequency of SLE in the general population of Australia has been reported to be notably lower than contemporary estimates in countries such as the United States or United Kingdom, at 19 to 39 per 100,000 as opposed ...
Lucinda Roper, Rachel Black, Joanna Tieu, Winnie Chen, Matthew Parker, Catherine Hill, Natasha Nassar, Mandana Nikpour   +7 more
wiley   +1 more source