Results 121 to 130 of about 2,960,910 (293)

Comprehensive characterization of circulating tumor cells and cell‐free DNA in patients with metastatic melanoma

Molecular Oncology
Advances in therapeutic approaches for melanoma urge the need for biomarkers that can identify patients at risk for recurrence and to guide treatment. The potential use of liquid biopsies in identifying biomarkers is increasingly being recognized.
Manouk K. Bos, Jaco Kraan, Martijn P. A. Starmans, Jean C. A. Helmijr, Noortje Verschoor, Maja J. A. De Jonge, Arjen Joosse, Astrid A. M. van derVeldt, Peter A. W. teBoekhorst, John W. M. Martens, Stefan Sleijfer, Saskia M. Wilting   +11 more
doaj   +1 more source

The interplay of circulating tumor DNA and chromatin modification, therapeutic resistance, and metastasis

Molecular Cancer, 2019
Peripheral circulating free DNA (cfDNA) is DNA that is detected in plasma or serum fluid with a cell-free status. For cancer patients, cfDNA not only originates from apoptotic cells but also from necrotic tumor cells and disseminated tumor cells that ...
Lei Zhang, Yiyi Liang, Shifu Li, Fanyuan Zeng, Yongan Meng, Ziwei Chen, Shuang Liu, Yongguang Tao, Fenglei Yu   +8 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Current status of liquid biopsies for the detection and management of prostate cancer

Cancer Management and Research, 2019
Yi-Tsung Lu, Kevin Delijani, Andrew Mecum, Amir GoldkornDivision of Medical Oncology, Department of Medicine, Keck School of Medicine and Translational and Clinical Science Program, USC Norris Comprehensive Cancer Center, University of Southern ...
Lu YT, Delijani K, Mecum A, Goldkorn A
doaj  

Advances in Liquid Biopsy and its Clinical Application in the Diagnosis 
and Treatment of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2016
With the advances of technology, great progresses have been made in liquid biopsy in recent years. Liquid biopsy is currently playing a more and more important role in early diagnosis and treatment of cancer.
Difan ZHENG, Haiquan CHEN
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes.

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability.
Xin Hu (38924), Yuanxin Xi (255031), Pedro Rocha (386032), Monique B Nilsson (18126607), Yael Raviv (18126616), Veronique Hofman (258841), John V Heymach (13586320), Mina Gaga (2938956), Bingnan Zhang (15161805), Paul Hofman (103032), Christine M Lovly (18126598), Edurne Arriola (632850), Jing Wang (6206297), Vasileios Panagoulias (18126613), Jianjun Zhang (220300), Marcos R Estecio (18126589), Hai Tran (470946), Kyle Concannon (15162981), Ignacio I Wistuba (18126622), Maria Gabriela Raso (14886905), Catherine A Schnabel (18126619), Peter Van Loo (9838), Azusa Tanimoto (14936243), Lixia Diao (184400), Natalie I Vokes (17808782), Adam Wasserstrom (27739), Whitney Elisabeth Lewis (18126604), Kimie Kondo (195898), Simon Heeke (8460396), Danny Frumkin (15144570), Prasad Kopparapu (524553), Ildikó Horváth (530804), Maarten Jansen (18126610), Qi Wang (22418), Benjamin B Morris (18126592), Allison Stewart (50114), Carl M Gay (18126586), Siqi Lai (18126595), Luana Guimaraes De Sousa (18126601), Aharona Shuali (15144567), Ximing Tang (253548), Lauren A Byers (17532391)   +41 more
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Decoding Glioblastoma Through Liquid Biopsy: Molecular Insights and Clinical Prospects

Cells
Liquid biopsy (LB) offers a minimally invasive approach to characterizing and monitoring glioblastoma (GB), a tumor marked by extensive heterogeneity, limited surgical accessibility and rapid molecular evolution.
Tomasz Wasiak, Maria Jaskólska, Kamil Filiks, Jakub Bartkowiak, Adrianna Rutkowska   +4 more
doaj   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source