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Circulating Tumor Cells and Circulating Tumor DNA in Colorectal Cancer
Expert Review of Precision Medicine and Drug Development, 2016ABSTRACTGenetic alterations in cancers serve as useful biomarkers in evaluating diagnosis, prognosis, and therapeutics. Genotyping tumour biopsies has become a routine practice in clinical oncology; however, it can only provide a spatially and temporally limited snapshot of the tumour achieved through an invasive procedure at a single time point ...
Nur-Afidah Mohamed Suhaimi, Min-Han Tan
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DNA Clutch Probes for Circulating Tumor DNA Analysis
Journal of the American Chemical Society, 2016Progress toward the development of minimally invasive liquid biopsies of disease is being bolstered by breakthroughs in the analysis of circulating tumor DNA (ctDNA): DNA released from cancer cells into the bloodstream. However, robust, sensitive, and specific methods of detecting this emerging analyte are lacking. ctDNA analysis has unique challenges,
Jagotamoy, Das +3 more
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Advances in Circulating Tumor DNA Analysis
2017The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might revolutionize cancer care with respect to early detection, identification of minimal residual disease, assessment of treatment response, and monitoring tumor evolution.
Samantha, Perakis +3 more
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Clinical Interest of Circulating Tumor DNA in Oncology
Archives of Medical Research, 2018Genetic alterations in tumors, as predictor of response to targeted-therapies or as prognostic markers, are clinically relevant to determine adequate therapeutic management. Tumor biopsy is currently the golden standard for somatic alterations assessment, but this approach is invasive and does not consider tumor heterogeneity.
Franczak, Claire +5 more
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Circulating tumor DNA analysis of neuroendocrine tumors.
Journal of Clinical Oncology, 2019e15698 Background: Neuroendocrine tumors (NETs) and carcinomas (NECs) are a diverse group of tumors with an equally diverse biology and clinical behavior. Data on tissue-based genomic profiling of NETs exists, however, there is limited data using circulating tumor DNA (ctDNA) technology.
Jason Scott Starr +3 more
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Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA
2021Cancer is associated with gene mutations, and the analysis of tumor-associated mutations is increasingly used for diagnostic, prognostic, and treatment purposes. These molecular landscapes of solid tumors are currently obtained from surgical or biopsy specimens.
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Utility of Circulating Tumor DNA in Appendiceal Tumors
Journal of Gastrointestinal Surgery, 2023Neal Bhutiani +6 more
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Updates on Circulating Tumor DNA Assessment in Lymphoma
Current Hematologic Malignancy Reports, 2018The use of circulating tumor DNA (ctDNA) for the purposes of diagnosis, prognosis, assessment of treatment response, and monitoring for relapse is a new and developing field in lymphoma. This review aims to summarize many of the most recent advances in ctDNA applications.Recent studies have demonstrated the use of ctDNA assessment across many lymphoma ...
Justin M, Darrah, Alex F, Herrera
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Heather A Parsons +2 more
exaly
[Circulating DNA, telomerase of circulating tumor cells and early diagnosis of tumors].
Ai zheng = Aizheng = Chinese journal of cancer, 2004The increase of circulating DNA levels, the mutations of tumor characteristic genes and the telomerase expression of circulating tumor cells can be detected not only in advanced stage but also in early stage of tumors. The combinational detection of circulating DNA and telomerase of circulating tumor cells is useful for the early diagnosis of tumors.
Zhong, Zhang, Yuan, Yuan
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