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2016
Circulating cell-free DNA (ccfDNA)--first identified in 1947--is "naked" DNA that is free-floating in the blood, and derived from both normal and diseased cells. In the 1970s, scientists observed that patients with cancer had elevated levels of ccfDNA as compared to their healthy, cancer-free counterparts.
Heather A, Parsons +2 more
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Circulating cell-free DNA (ccfDNA)--first identified in 1947--is "naked" DNA that is free-floating in the blood, and derived from both normal and diseased cells. In the 1970s, scientists observed that patients with cancer had elevated levels of ccfDNA as compared to their healthy, cancer-free counterparts.
Heather A, Parsons +2 more
openaire +2 more sources
Circulating Tumor DNA and Hepatocellular Carcinoma
Seminars in Liver Disease, 2019AbstractThere is a clear and unmet need for biomarkers in hepatocellular carcinoma (HCC). Circulating cell free deoxyribonucleic acid (cfDNA) is a fragmented DNA subtype, found in the blood circulation. Circulating tumor DNA (ctDNA) is the fraction of total cfDNA, which originates from the primary tumor or metastases in patients with cancer.
Ju Dong, Yang +2 more
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Circulating Tumor Cells and Circulating Tumor DNA in Colorectal Cancer
Expert Review of Precision Medicine and Drug Development, 2016ABSTRACTGenetic alterations in cancers serve as useful biomarkers in evaluating diagnosis, prognosis, and therapeutics. Genotyping tumour biopsies has become a routine practice in clinical oncology; however, it can only provide a spatially and temporally limited snapshot of the tumour achieved through an invasive procedure at a single time point ...
Nur-Afidah Mohamed Suhaimi, Min-Han Tan
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DNA Clutch Probes for Circulating Tumor DNA Analysis
Journal of the American Chemical Society, 2016Progress toward the development of minimally invasive liquid biopsies of disease is being bolstered by breakthroughs in the analysis of circulating tumor DNA (ctDNA): DNA released from cancer cells into the bloodstream. However, robust, sensitive, and specific methods of detecting this emerging analyte are lacking. ctDNA analysis has unique challenges,
Jagotamoy, Das +3 more
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Advances in Circulating Tumor DNA Analysis
2017The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might revolutionize cancer care with respect to early detection, identification of minimal residual disease, assessment of treatment response, and monitoring tumor evolution.
Samantha, Perakis +3 more
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Circulating tumor DNA analysis of neuroendocrine tumors.
Journal of Clinical Oncology, 2019e15698 Background: Neuroendocrine tumors (NETs) and carcinomas (NECs) are a diverse group of tumors with an equally diverse biology and clinical behavior. Data on tissue-based genomic profiling of NETs exists, however, there is limited data using circulating tumor DNA (ctDNA) technology.
Jason Scott Starr +3 more
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Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA
2021Cancer is associated with gene mutations, and the analysis of tumor-associated mutations is increasingly used for diagnostic, prognostic, and treatment purposes. These molecular landscapes of solid tumors are currently obtained from surgical or biopsy specimens.
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Utility of Circulating Tumor DNA in Appendiceal Tumors
Journal of Gastrointestinal Surgery, 2023Neal Bhutiani +6 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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