Results 241 to 250 of about 2,960,910 (293)

The role of circulating tumor DNA (ctDNA) to detect minimal residual disease in locally advanced gastroesophageal carcinoma: the BUTTERFLY study. [PDF]

ESMO Gastrointest Oncol
Puccini A, Paracchini L, Alfieri R, Ancona L, Daprà V, Migliaccio G, Cammarota A, Mannarino L, Bartolini M, Miele V, Airaghi C, Beltrame L, Rella A, Mella G, Piemontese M, Pansa A, Garbarino GM, Basato S, Capogreco A, Franceschini D, D'Orazio F, Fraticelli S, Pistillo D, Spaggiari P, Laghi A, Hassan C, Scorsetti M, Repici A, Janjigian YY, Castoro C, Santoro A, Marchini S.   +31 more
europepmc   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Toward predicting colorectal cancer recurrence: the α-CORRECT study of circulating tumor DNA - a plain language summary of the original publication. [PDF]

Ther Adv Med Oncol
Grigorieva JA, Hall DW, Choudhry O, Birkey Reffey S, Lubcke N, Young G, Palomares MR, Baehner FL, Schoen RE, Diergaarde B.   +9 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Circulating tumor DNA-guided response evaluation in patients with previously treated gastroesophageal adenocarcinoma. [PDF]

Gastric Cancer
Iden CR, Øgaard N, Mustafa SM, Elle IC, Yilmaz M, Nordsmark M, Henriksen T, Kruse T, Thomassen M, Pfeiffer P, Andersen CL, Bæksgaard L, Qvortrup C, Mau-Sørensen M.   +13 more
europepmc   +1 more source

An alignment-free strategy for circulating tumor DNA detection and tumor fraction estimation from whole-genome sequencing data. [PDF]

PLoS Comput Biol
Oroperv C, Frydendahl A, Henriksen TV, Santacatterina G, Antonello A, Calonaci N, Rasmussen MH, Caravagna G, Andersen CL, Besenbacher S, IMPROVE-consortia.   +10 more
europepmc   +1 more source

Circulating Tumor DNA for Minimal Residual Disease Detection and Recurrence Prediction in Upper Gastrointestinal Cancers: A Scoping Review. [PDF]

J Clin Med
Hadjigeorgiou L, Yerolatsite M, Torounidou N, Zarkavelis G, Schizas D, Tatsis V, Rausei S, Vlachos K, Lianos GD.   +8 more
europepmc   +1 more source

Assessment of methylated BCAT1 and IKZF1 circulating tumor DNA as a prognostic biomarker in esophagogastric adenocarcinomas. [PDF]

Dis Esophagus
Chan MM, Roy AC, Watson DI, Bright T, Sheehan-Hennessy L, Young GP, Hussey D, Pedersen SK, Winter JM, Symonds EL.   +9 more
europepmc   +1 more source

Circulating Tumor DNA in Upper Tract Urothelial Carcinoma: A Framework for Precision Perioperative Management. [PDF]

Cancers (Basel)
Prakash A, Cherico A, Ayanambakkam A, Polimera HV.   +3 more
europepmc   +1 more source