Results 231 to 240 of about 305,738 (309)

Circulating tumor DNA informs clinical practice in patients with recurrent/metastatic gastroesophageal cancers. [PDF]

Cancer
Mehta R, Rivero-Hinojosa S, Dayyani F, Ferguson J, Shariff B, Aushev VN, Budde GL, Ortiz JB, George GV, Sharma S, Jurdi AA, Liu MC, Drengler RL, Klempner SJ.   +13 more
europepmc   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Circulating Tumor DNA as a Prognostic and Predictive Biomarker in Lung Cancer. [PDF]

Cancers (Basel)
Dhillon P, Du S, Cheng H.
europepmc   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Circulating tumor DNA dynamics predict pathological response and guide therapy personalization in the neoadjuvant setting. [PDF]

Discov Oncol
Ahmed HM, Al-Hussainy AF, Mustafa WW, Jyothi SR, Nayak PP, Janney JB, Singh G, Sinha A, Sameer HN, Salih RM, Adil M, Salajegheh P.   +11 more
europepmc   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma. [PDF]

Nat Commun
Romesser PB, Bercz A, Alvarez J, Kostrzewa CE, Adames A, Liu EK, Ho YJ, Mohan N, Reyngold M, Yaeger R, Roth O'Brien DA, Cuaron JJ, Zinovoy M, Olinger C, Ravella R, Lisanti J, Zambare W, Aushev VN, Sharma S, Malhotra M, Rivero-Hinojosa S, Schauer N, Jurdi A, Liu MC, Wu A, Williams V, Connell L, Pappou E, Rao D, Segal NH, Paty PB, Weiser MR, Cercek A, Marcet J, Garcia-Aguilar J, Crane CH, Gonen M, Smith JJ, Tuli R.   +38 more
europepmc   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Advancing gastrointestinal cancer diagnosis and treatment: a narrative review of circulating tumor DNA in gastrointestinal malignancies. [PDF]

Transl Gastroenterol Hepatol
McSween Z, Antoine-Pepeljugoski C, Komorowski A, King D, Tchelebi L.   +4 more
europepmc   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source