Results 41 to 50 of about 250,499 (303)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Emergence of decadal linkage between Western Australian coast and Western–central tropical Pacific

Nature Communications
The impact of interbasin linkage on the weather/climate and ecosystems is significantly broader and profounder than that of only appearing in an individual basin. Here, we reveal that a decadal linkage of sea surface temperature (SST) has emerged between
Yuewen Ding, Pengfei Lin, Hailong Liu, Bo Wu, Yuanlong Li, Lin Chen, Lei Zhang, Aixue Hu, Yiming Wang, Yiyun Yao, Bowen Zhao, Wenrong Bai, Weiqing Han   +12 more
doaj   +1 more source

A Novel Approach to Investigating Transport of Lost Circulation Materials in Rough Fracture

Energies, 2018
The drilling fluid loss or lost circulation via fractures is one of the critical engineering problems in the development of deep oil and gas resources. The conventional treatment is to introduce granular lost circulation material (LCM) into the drilling ...
Yi Feng, Gao Li, Yingfeng Meng, Boyun Guo   +3 more
doaj   +1 more source

Is the Kelvin Theorem Valid for High-Reynolds-Number Turbulence? [PDF]

, 2006
The Kelvin-Helmholtz theorem on conservation of circulations is supposed to hold for ideal inviscid fluids and is believed to be play a crucial role in turbulent phenomena, such as production of dissipation by vortex line-stretching.
Chen, Shiyi, Eyink, Gregory L., Wan, Minping, Xiao, Zuoli   +3 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Atmospheric Circulation and Tides of "51Peg b-like" Planets [PDF]

, 2002
We examine the properties of the atmospheres of extrasolar giant planets at orbital distances smaller than 0.1 AU from their stars. We show that these ``51Peg b-like'' planets are rapidly synchronized by tidal interactions, but that small departures from
A. P. Showman, Allard, Banfield, Barman, Bodenheimer, Brown, Burrows, Burrows, Charbonneau, Dermott, Dowling, Geballe, Gold, Goldreich, Goukenleuque, Guillot, Guillot, Henry, Hubbard, Ingersoll, Ioannou, Liebert, Lodders, Lubow, Maeder, Marcy, Marley, Peale, Polvani, Rhines, Schweitzer, Seager, Seager, T. Guillot, Tittemore, Zahn   +35 more
core   +2 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

FEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

Numerical Simulation Study of Seafloor Hydrothermal Circulation Based on HydrothermalFoam: A Case Study of the Wocan-1 Hydrothermal Field, Carlsberg Ridge, Indian Ocean

Journal of Marine Science and Engineering, 2023
Deep-sea hydrothermal circulation plays a pivotal role in the material and energy exchange in deep-sea environments, exerting significant influence on the evolution of seawater chemistry and global climate dynamics. Based on existing data and assumptions,
Haoyang Zeng, Peng Hu, Zhiguo He, Jinrong Yao, Zhiying Yang   +4 more
doaj   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source