Results 101 to 110 of about 149 (146)

Bioorthogonal Postlabeling Reveals Nuclear Localization of a Highly Cytotoxic Half‐Sandwich Ir(III) Tetrazine Complex in Live Cells

ChemBioChem, EarlyView.
This study reports the synthesis of five tetrazine‐coordinated, half‐sandwich iridium complexes and extensively describe their reactivity. Live cell fluorescent bioorthogonal labeling reveals the nuclear tropism of the most cytotoxic complex. Intracellular imaging of anticancer metallodrugs often relies on prelabeling with organic fluorophores, which ...
Alfonso Annunziata, Sadek Amhaz, Jérémy Forté, Geoffrey Gontard, Romain Morichon, Joëlle Sobczak‐Thépot, Michèle Salmain   +6 more
wiley   +1 more source

Harnessing Organometallic Au(III) Complexes as Precision Scaffolds for Next‐Generation Therapeutic and Imaging Agents

ChemBioChem, EarlyView.
Cyclometalated gold(III) complexes offer a versatile platform for selective biological interactions, including cysteine arylation, redox modulation, and enzyme inhibition. This review explores their roles in anticancer, antimicrobial, and protein modification strategies, highlighting their ability to disrupt metabolic pathways, modulate aquaporins, and
Sophie R. Thomas, Riccardo Bonsignore
wiley   +1 more source

Cyclopentadienyl Half‐Sandwich Rhodium(III) Azopyridine Anticancer Complexes with Activity Tuned by Ligand Substituents

ChemCatChem, EarlyView.
The chemical and biological activity of this family of half‐sandwich organorhodium complexes depends markedly on the substituents on the cyclopentadienyl and azopyridine ligands, including activation by hydrolysis, lipophilicity, potency toward lung, ovarian, prostate cancer, and normal cells, cell accumulation of Rh, and catalytic oxidation of ...
Edward C. Lant, Russell J. Needham, Zijin Zhang, James P. C. Coverdale, Guy J. Clarkson, Ian Bagley, Robert Dallmann, Peter J. Sadler   +7 more
wiley   +1 more source

Mitochondria‐Catalyzed Activation of Anticancer Prodrugs

ChemCatChem, EarlyView.
Prodrug C is a water soluble, monomeric compound accumulating in mitochondria of cancer cells, where it is activated in the reaction with mitochondrial H2O2. The activation leads to the release of camptothecin that causes cell cycle arrest in G2 phase and cancer cell death.
Michael Raucheisen, Dina Attia, Marlies Körber, Alejandra Aroca Crevillén, Andrés Hidalgo, Frank Beierlein, Petra Imhof, Andriy Mokhir   +7 more
wiley   +1 more source

Introduction of a Phosphine Group onto the Ferrocene Moiety in Ferrociphenol Opens Access to New Heterobimetallic Complexes with Anticancer Activity

ChemistryEurope, EarlyView.
Modification of the ferrociphenol structure by a phosphine moiety appended to the originally unsubstituted cyclopentadienyl ring of the ferrocene unit represents a new and useful modification of this potent anticancer agent and opens a way to the preparation of new biologically active derivatives (e.g., phosphonium salts) and, mainly, heterobimetallic ...
Magda Křelinová, Michèle Salmain, Petr Štěpnička, Ivana Císařová, Benoît Bertrand, Jiří Schulz   +5 more
wiley   +1 more source

Exploring the Impact of Phenanthroline‐based Glycoconjugated Ru(II) Polypyridyl Photosensitizers on Metastasis‐related Processes”

Chemistry – A European Journal, Accepted Article.
Novel water‐soluble, phosphorescent ruthenium(II) polypyridyl‐glycoconjugates of general formula [Ru{N‐(1,10‐phenanthroline)}2{N‐(1,10‐phenanthrolin‐5‐yl)‐β‐glycopyranosylamine}][Cl]2 (glycopyranosyl = D‐glucopyranosyl (1), D‐mannopyranosyl (2), L‐rhamnopyranosyl (3), L‐xylopyranosyl (4) and 2,3,4‐tri‐O‐acetyl‐L‐xylopyranosyl (5)) and corresponding ...
Elena de la Torre-Rubio, María-Selma Arias-Pérez, Lourdes Gude, Tomás Cuenca, Cristina García-Iriepa, Eva Royo   +5 more
wiley   +1 more source

Protonation of Pt(IV) Anticancer Complexes Assayed by Vibrational Ion Spectroscopy

ChemPlusChem, EarlyView.
Protonated Pt(IV) complexes with various equatorial and axial ligands were characterized by IR ion spectroscopy and DFT. Protonation typically occurs at carboxylato ligands, eventually increasing their substitution propensity. However, the carboplatin‐derived complex showed mixed protomer populations, highlighting the significance of ligand selection ...
Davide Corinti, Elisabetta Gabano, Barbara Chiavarino, Maria Elisa Crestoni, Domenico Osella, Simonetta Fornarini   +5 more
wiley   +1 more source

Sustainable Synthesis, Characterization, Cellular Effects of Gold Nanoparticles and Their Applications as Therapeutics in Cancer Therapy

ChemPlusChem, EarlyView.
Gold nanoparticles (AuNPs) are widely used in biomedicine, electronics, catalysis, and environmental science. Conventional synthesis relies on harsh chemicals, driving interest in eco‐friendly methods using plants, bacteria, fungi, and algae. Biomolecules like polyphenols, proteins, and fatty acids aid nanoparticle synthesis under mild conditions. This
Youfeng Yue, Akihiro Moriyama, Marie Mita, Yue Yu   +3 more
wiley   +1 more source

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Clinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler, Caíque Manóchio, Bruno Miwa, Guilherme Belfort‐Almeida, Lucas Faria‐Costa, Cesar Sanchez, Carlos Padilla, Omar Caceres, Eduardo Tarazona‐Santos, Heinner Guio, Timothy D. O'Connor, Fernanda Rodrigues‐Soares   +11 more
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source