Results 181 to 190 of about 416,036 (340)

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

Carboplatin binding to a model protein in non-NaCl conditions to eliminate partial conversion to cisplatin, and the use of different criteria to choose the resolution limit

, 2013
Hen egg white lysozyme (HEWL) co-crystallisation conditions of carboplatin without sodium chloride (NaCl) have been utilised to eliminate partial conversion of carboplatin to cisplatin observed previously.
Diederichs, Kay, Helliwell, John R, Kroon-Batenburg, Loes M. J, Schreurs, Antoine M. M, Tanley, Simon W. M   +4 more
core  

Non‐Destructively Quantifying the Whole‐Course Growth and Drug‐Response of PDOs by an Automatic Microfluidic System Utilizing Chemiluminescence Detection

Advanced Science, EarlyView.
The detection of secreted biomarkers enables molecular variations monitoring of organoid status. In this study, the non‐destructive quantification for the whole‐course growth and drug‐response of PDOs is first realized using a multifunctional microfluidic chip‐based system(ASMO) that integrates culturing, drug incubation, and biomarker detection ...
Yu Zhang, Daoyun Wang, Zhicheng Huang, Nan Zhang, Zhina Wang, Xin Wu, Anlan Zhang, Runzhi Yang, Tong Li, Zhibo Zheng, Yuxiao Lin, Naixin Liang, Zewen Wei   +12 more
wiley   +1 more source

Identification of microprotein-coding intronic polyadenylation isoforms and function in genotoxic anticancer drug response. [PDF]

Genome Biol
Devaux A, Tanaka I, Fouilleul Q, Heneman-Masurel A, Cadix M, Michallet S, Chakraborty A, Labbé CM, Fontrodona N, Sahoo S, Claude JB, Deloger M, Gestraud P, Tessier L, Mortada H, Lameiras S, Raynal V, Baulande S, Servant N, Auboeuf D, Eymin B, Vagner S, Dutertre M.   +22 more
europepmc   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

Advanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang, Shi‐Hao Bai, Shu‐Jin Song, Xiao‐Li Zhang, Xue‐Ying Shang, Zhao‐Ning Lu, Xiao‐Fang Cui, Xin‐Le Zhu, Ze‐Guang Han   +8 more
wiley   +1 more source

CRISPR/Cas9 library screening reveals that STK19 has synergistic antitumor effects when combined with cisplatin on tongue squamous cell carcinoma. [PDF]

J Transl Med
Li C, Peng W, Zhong Z, Zhang C, Wang X, Qin R, Lei Q, Lv J, Liu F, Zhao Y, Lv Z, Li C, Yang S, Zhang H, Tao Z, Sun C.   +15 more
europepmc   +1 more source

Extracellular Vesicle‐Packaged circTAX1BP1 from Cancer‐Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells

Advanced Science, EarlyView.
This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan, Jin‐hao Yu, Dong Hou, Ye‐quan Xie, Dong‐ming Lai, Fang Zheng, Bin Yang, Jin‐tao Zeng, Yang Chen, Shu‐hong Lu, Guang‐yu Zhong, Fang‐hai Han, Sheng‐ning Zhou   +12 more
wiley   +1 more source

Non-canonical dihydrolipoyl transacetylase promotes chemotherapy resistance via mitochondrial tetrahydrofolate signaling. [PDF]

Nat Commun
Hwang JS, Kang J, Kim J, Eun K, West S, Bacho HE, Avalos V, Shuff S, Shin DM, Saba NF, Magliocca KR, Qu CK, Fu H, Ramalingam SS, Ivanov AA, Hitosugi T, Kang S.   +16 more
europepmc   +1 more source

Advanced Gastric Carcinoma Chemotherapy with Cisplatin, Mitomycin C, BCNU, and 5-Fluorouracil in Combination [PDF]

, 1987
Re Hwe Kim, Yun Woo Lee, Dong Chul Lee, Nam Ho Kim, Jae Sung Choi, Sun Ki Joo, Chul Soo Kim   +6 more
openalex   +1 more source

Emerging Nanozyme Strategies for Precision Breast Cancer Treatment

Advanced Science, EarlyView.
Different types of nanozymes‐mediated chemotherapy, photothermal therapy, immunotherapy, and multiple combined therapies for the effective treatment of breast cancer. Abstract Breast cancer, the most common malignant tumor among women worldwide, poses a significant challenge to public health due to its high incidence and mortality rates.
Jian Zang, Zhaozhou Ren, Haibo Wang, Xing Yang, Yang Song, Jun Liao, Xiaoying Li   +6 more
wiley   +1 more source