Results 191 to 200 of about 366,991 (303)

Tislelizumab combined with gemcitabine plus cisplatin for muscle-invasive upper tract urothelial carcinoma: A retrospective single-center cohort analysis. [PDF]

J Int Med Res
Zhang J, Xiao Y, Cai D, Zhu H, Zhong W.
europepmc   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Pseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics. [PDF]

Cell Death Dis
Sreeram I, Plans-Marin S, Cruz-Rodríguez M, Aliagas E, Palau-Gallinat D, Muñoz-Pinedo C, Nadal E.   +6 more
europepmc   +1 more source

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Distortion product otoacoustic emission (DPOAE) reveals hearing loss up to 16 kHz in pediatric chemotherapy patients. [PDF]

Sci Rep
Hecker DJ, Remke MKH, Linxweiler M, Furtwängler R, Akrasu Y, Schöndorf D, Graf N, Krieter D, Oberkircher N, Schick B, Bozzato A, Simon A.   +11 more
europepmc   +1 more source

Baicalin chemosensitivity enhancement of cisplatin in bladder cancer via autophagy flux inhibition. [PDF]

Front Pharmacol
Zhuang J, Wang H, Chen Z, Wang J, Zheng X, He K, Xie D, Chen Q, Deng S, Wu J, Zheng X, Dai Y.   +11 more
europepmc   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Platycodin D sensitizes head and neck squamous cell carcinoma to cisplatin by inducing autophagy arrest. [PDF]

Oncol Rep
Bae M, Lee MK, Jeong MG, Lee Y, Joo H, Lee YC, Lee JW, Kim SI, Ko SG, Eun YG.   +9 more
europepmc   +1 more source

Stereochemical Modulation of Palladacyclopentadienyl Complexes Bearing Diphosphine Ligands: A Key to Enhanced DNA Interaction and Anticancer Activity

European Journal of Inorganic Chemistry, EarlyView.
A modular library of structurally robust palladacyclopentadienyl Pd(II) complexes bearing achiral and chiral diphosphines was developed, revealing a strong influence of diphosphine design and ligand chirality on cytotoxicity and selectivity against ovarian cancer cells, including platinum‐resistant models.
Stefania Mautone, Martina Scianna, Isabella Caligiuri, Laura Orian, Pablo Nogara, Nicola Demitri, Flavio Rizzolio, Thomas Scattolin   +7 more
wiley   +1 more source

Ubiquitin-mediated stabilization of KDM5B drives chemoresistance via repression of dual-specificity phosphatase 4 in ovarian cancer. [PDF]

Signal Transduct Target Ther
Yoo J, Kim GW, Jeon YH, Kim J, Luo E, Lee SW, Oh SY, Choi J, Kim K, Kwon SH.   +9 more
europepmc   +1 more source