Results 181 to 190 of about 256,231 (309)

Ultra‐Wideline 2D Correlations Among Low‐γ Species in Solid‐State NMR via the Progressive Saturation of a Common Proton Reservoir

Chemistry – A European Journal, EarlyView.
This study introduces PROSPECT, a 2D solid‐state NMR method that correlates MHz‐wide, low‐γ anisotropic powder patterns. PROSPECT operates by progressively depleting a shared 1H dipolar‐order reservoir via two independently stepped cross‐polarizing offsets, yielding homonuclear and heteronuclear correlations without requiring direct transfers or even ...
Rihards Aleksis, Lucio Frydman
wiley   +1 more source

Synthesis of cholic acid - cisplatin conjugates for potential liver selective drug uptake

reservedThe synthesis of cholic acid – cis-Pt conjugates is a promising attempt to reduce cis-Pt severe side effects. This conjugation makes the chemotherapeutic agent subject to enterohepatic circulation, conferring to the drug organotropic ...
SCHIAVINATO, CHIARA
core  

Isoform Specificity of a Compound Targeting Actin Filaments Containing Tropomyosin Tpm1.8/1.9

Cytoskeleton, EarlyView.
ABSTRACT The unbranched actin filaments in mammalian cells are usually composed of co‐polymers of a specific tropomyosin isoform with actin. Genetic manipulation has revealed that the tropomyosins largely define the functional properties of actin filaments in an isoform‐specific, non‐redundant manner.
Jeff Hook, Edna C. Hardeman, Peter W. Gunning   +2 more
wiley   +1 more source

Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction. [PDF]

Front Mol Neurosci
Oliveros A, Loncar I, Mostafa M, Poleschuk M, Corujo AM, Qin B, Song J, Tischfield MA, Jang MH.   +8 more
europepmc   +1 more source

ESM1 drives cisplatin resistance and ferroptosis resistance via ERBB2/FAK/SRC/HSPB1/NF-κB signaling in ovarian cancer. [PDF]

iScience
Zhang J, Tan Y, Yang H, Tang X, Liu D, Zhou W, Zeng T, Liu X, Li M, Chen X, Zou J, Li Y.   +11 more
europepmc   +1 more source

Systematic Evaluation of Data and Trial Fitness for Oncology Trial Emulation: Empirical Findings from the CARE Initiative

Clinical Pharmacology &Therapeutics, EarlyView.
The Coalition to Advance Real‐World Evidence through Randomized Controlled Trial Emulation (CARE) Initiative seeks to advance understanding of when real‐world data (RWD) can generate valid treatment effectiveness estimates by emulating completed oncology randomized controlled trials (RCTs).
Natalie Levy, Paige Sheridan, Ulka Campbell, David Lenis, Inish O'Doherty, Adina Estrin, Nileesa Gautam, Monica Iyer, Sarah McDonald, Andrew Belli, Gillis Carrigan, K. Arnold Chan, James Chen, Victoria Chia, Neil Dhopeshwarkar, Joy Eckert, Laura Fernandes, Joel Greshock, Rachele Hendricks‐Sturrup, Jenny Huang, XiaoLong Jiao, Sajan Khosla, Orsolya Lunacsek, Lynn McRoy, Yanina Natanzon, Osayi Ovbiosa, Nelson Pace, Simone Pinheiro, Megan Rees, Jennifer Rider, Mothaffar Fahed Rimawi, Travis Robinson, Carla Rodriguez‐Watson, Chithra Sangli, Khaled Sarsour, Sebastian Schneeweiss, Mark Shapiro, Mark Stewart, Aliki Taylor, C. K. Wang, Shirley Wang, Yiduo Zhang, Ann Madsen   +42 more
wiley   +1 more source

Reprogramming Transcriptional Networks via CREB1 Lactylation at K122 Activates HMGB1-Mediated NETosis and Chemoresistance. [PDF]

Int J Biol Sci
Wang JM, Zhao FY, Zhang Q, Yuan Y, Li BQ, Liu N, Li JJ, Liu C, Wang HQ.   +8 more
europepmc   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

CDK4 Mediates Cisplatin Resistance in Renal Cell Carcinoma (RCC) Cells by Regulating the ASH1L-CTR1 Axis. [PDF]

Oncol Res
Zeng W, Li X, Cai H, Zhou Q, Sun S, Li P, Li S, Chen Z.   +7 more
europepmc   +1 more source

OMIP‐121: Immune Phenotyping of Canine Peripheral Leukocytes by Mass Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Dogs are a critical non‐rodent species used in preclinical safety studies, particularly, in the pharmaceutical field, due to their physiological, metabolic, and immunological similarities to humans. As such, immunophenotyping of canine peripheral blood mononuclear cells (PBMCs) plays a crucial role in translational research, immune monitoring,
Huyen Thuc Tran Luong, Dominique Revets, Sofie Vercammen, Ario de Marco, Hilde de Rooster, Antonio Cosma   +5 more
wiley   +1 more source