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Metallothioneins and Cisplatin Resistance
1991Intrinsic and acquired resistance to antineoplastic agents has severely limited our ability to cure solid tumors. Cis-diamminedichloroplatinum (cisplatin) represents one of the most efficacious agents for the treatment of solid tumors especially testicular, ovarian, bladder, and head and neck carcinomas.
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Biochemical and Molecular Mechanisms of Cisplatin Resistance
2002According to the DISCOVERY Anticancer Drug Screen of the National Cancer Institute in the USA, the inorganic antitumor agent cisplatin(cisdiammine-dichloro-platinum(II); Figure 1) and its analogs fall into at least 13 clustered regions, each reflecting a distinct mechanism of action1. Many of these analogs have not been investigated in depth to unravel
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Cellular and molecular determinants of cisplatin resistance
European Journal of Cancer, 1998Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer drugs. However, the acquisition or presence of resistance significantly undermines the curative potential of these drugs against many malignancies. Multiple potential mechanisms of resistance have been identified at the cellular and molecular levels. Alterations in
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Cisplatin resistance reversal with treatment of Citric acid in cisplatin-resistant cell lines
ABSTRACT Gastric cancer (GC) is a prevalent and aggressive malignancy with significant morbidity and mortality rates, posing a major threat to human health globally. While surgery remains the preferred clinical treatment, chemotherapy continues to be the cornerstone for perioperative care, adjuvant therapy, and palliative treatment for ...Siddhant Chaturvedi, Krishna Venka
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circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma
Molecular Therapy, 2022Fan Yin, Xiangdong Li, Lei Yu
exaly
Cisplatin resistance and DNA repair
Cancer Treatment Reviews, 1997Crul, M. +3 more
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Electrochemotherapy with cisplatin in the treatment of tumor cells resistant to cisplatin.
Anticancer research, 1999The aim of our study was to investigate the role of electroporation in the treatment of cisplatin resistant tumor cells in vitro. For this purpose we used well characterized human ovarian carcinoma IGROV I cells and their resistant subclone IGROV 1/DDP.
M, Cemazar, G, Sersa, D, Miklavcic
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