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Results 91 to 100 of about 9,594 (241)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source

The Importance of Rapid Consideration of Creutzfeldt- Jakob Disease in the Differential Diagnosis of Progressive Neurodegenerative Disease: A Case Report

International Journal of Medical Students, 2016
Background: Creutzfeldt-Jakob disease (CJD) is a prion disease characterized by misfolded proteins that lead to neurodegeneration and inevitable death. Classic sporadic CJD presents primarily with cognitive symptoms and ataxia without visual impairment ...
Arthur Joseph +4 more
doaj +1 more source

Economic and Biological Evaluation of Pheromone Trap Types for Western Bean Cutworm, Striacosta albicosta, Monitoring in Dry Edible Bean Fields

Entomologia Experimentalis et Applicata, Volume 174, Issue 7, Page 750-763, July 2026.
Pheromone trap use for monitoring Striacosta albicosta in dry edible beans was evaluated across multiple trap designs, lure replacement intervals, and insecticide timings. Bucket traps captured the most moths, yet trap counts poorly predicted crop damage.
Jeffrey D. Cluever +3 more
wiley +1 more source

Ring trial of 2nd generation RT‐QuIC diagnostic tests for sporadic CJD

, 2020
Orrú, Christina D. +21 more
openalex +2 more sources

HaloTag Fusion Enables Dynamic Analysis of Prion Protein Biosynthesis, Turnover, and Misfolding

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Prion protein (PrP) misfolding underlies fatal neurodegenerative diseases. We developed a HaloTag‐based PrP fusion enabling spatiotemporal labeling of distinct PrP populations in living cells. This system recapitulates native PrP biology, reveals early misfolding events in disease‐associated mutants, and allows mechanistic interrogation of PrP‐lowering
Antonio Masone, Eleonora Busani, Roberto Chiesa +2 more
wiley +1 more source

Identification of genomic differences between Campylobacter jejuni subsp. jejuni and C. jejuni subsp. doylei at the nap locus leads to the development of a C. jejuni subspeciation multiplex PCR method

BMC Microbiology, 2007
Background The human bacterial pathogen Campylobacter jejuni contains two subspecies: C. jejuni subsp. jejuni (Cjj) and C. jejuni subsp. doylei (Cjd). Although Cjd strains are isolated infrequently in many parts of the world, they are obtained primarily ...
Heath Sekou +3 more
doaj +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, Volume 73, Issue 6, June 2026.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1088-1105, June 2026.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source

Building a Robust Investigator‐Initiated Platform: The I‐CARE Experience

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1537-1546, June 2026.
Investigator‐initiated studies that include information collected by patients are rising, but limited data is available on patient and investigator experience in this setting. The I‐CARE cohort included patients with inflammatory bowel disease (IBD) monthly collecting clinical information in 15 countries for up to 6 years.
Julien Kirchgesner +906 more
wiley +1 more source

Seascape Connectivity Shapes Genetic and Species β‐Diversity in Tropical Reef Fishes

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Our study combines species occurrence data from five reef fish families with genomic SNP data for 19 species. A correlation between genetic and species β‐diversity emerges only in the Western Indian Ocean, where higher genetic β‐diversity and significant isolation by distance at both the population and community levels are detected.
Maurine Vilcot +16 more
wiley +1 more source

medicine
creutzfeldt-jakob syndrome
disease

pathology
humans
creutzfeldt-jakob disease

virology
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