Results 171 to 180 of about 10,819 (208)
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wu S +6 more
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Targeting Casein Kinase 1 (CK1) in Hematological Cancers [PDF]
International Journal of Molecular Sciences, 2020 The casein kinase 1 enzymes (CK1) form a family of serine/threonine kinases with seven CK1 isoforms identified in humans. The most important substrates of CK1 kinases are proteins that act in the regulatory nodes essential for tumorigenesis of hematological malignancies. Among those, the most important are the functions of CK1s in the regulation of Wnt
Pavlina Janovska +2 more
exaly +4 more sources
Newly Developed CK1-Specific Inhibitors Show Specifically Stronger Effects on CK1 Mutants and Colon Cancer Cell Lines [PDF]
International Journal of Molecular Sciences, 2019 Protein kinases of the CK1 family can be involved in numerous physiological and pathophysiological processes. Dysregulated expression and/or activity as well as mutation of CK1 isoforms have previously been linked to tumorigenesis. Among all neoplastic diseases, colon and rectal cancer (CRC) represent the fourth leading cause of cancer related deaths ...
Joachim Bischof +2 more
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Purification of CK1 by affinity chromatography on immobilised axin
Protein Expression and Purification, 2007 Members of the Casein Kinase 1 (CK1) family are implicated in the regulation of a variety of physiological processes like development and circadian rhythm, as well as in diseases like cancer and Alzheimer's disease. From that perspective, CK1 family members are interesting targets for potential chemotherapy.
Yoan Ferandin, Laurent Meijer
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Isoform specific phosphorylation of p53 by protein kinase CK1
Cellular and Molecular Life Sciences, 2009 The ability of three isoforms of protein kinase CK1 (alpha, gamma(1), and delta) to phosphorylate the N-terminal region of p53 has been assessed using either recombinant p53 or a synthetic peptide reproducing its 1-28 sequence. Both substrates are readily phosphoylated by CK1delta and CK1alpha, but not by the gamma isoform.
Andrea Venerando +2 more
exaly +6 more sources
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Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
Molecular Cell, 2022CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their misregulation contributes to cancer, neurodegenerative diseases, and sleep phase disorders. Here, we describe an evolutionarily conserved mechanism of CK1 activity: autophosphorylation of a threonine (T220 in human CK1δ) located at the N ...
Apirat Chaikuad +2 more
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CK1 Delta Inhibition: An Emerging Strategy to Combat Neurodegenerative Diseases
Future Medicinal Chemistry, 2022Due to the lengthening of average life expectancy, neurodegenerative diseases are constantly growing all over the world in terms of people affected, and have a significant impact on public health, with regard to disabilities, complexity of managing the disease and need for treatment.
Varano, Flavia +4 more
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Protein Kinase CK1 from Trypanosoma cruzi
Journal of Protein Chemistry, 2003A protein kinase activity, which uses casein as a substrate, has been purified to homogeneity from the epimastigote stage of Trypanosoma cruzi, by sequential chromatography on Q sepharose, heparin sepharose, phenyl sepharose, and alpha-casein agarose.
Maritza, Calabokis +3 more
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Differential Phosphorylation of Occludin and Tricellulin by CK2 and CK1
Annals of the New York Academy of Sciences, 2009In epithelial and endothelial cell layers tight junctions form selective apicolateral paracellular barriers separating luminal and extracellular spaces from the underlying tissues. Within the tight junctions the tetraspan transmembrane proteins occludin, claudins, and tricellulin form anastomosing strands of protein complexes, which interconnect ...
Max J, Dörfel +2 more
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