Results 181 to 190 of about 10,819 (208)

Achieving Effective and Selective CK1 Inhibitors Through Structure Modification

Future Medicinal Chemistry, 2021
Casein kinase 1 (CK1) is an extensively expressed serine/threonine kinase family, with six highly conserved isoforms of human CK1. Due to its involvement in many biological processes, CK1 is a promising target for several pathological states, including circadian sleep disorder, neurodegenerative diseases, cancer and inflammation.
Chenxi Du, Hongyu Yang, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Sun   +5 more
openaire   +2 more sources

Phosphorylation of multifunctional galectins by protein kinases CK1, CK2, and PKA

Analytical Biochemistry, 2014
Phosphorylation is known to have a strong impact on protein functions. We analyzed members of the lectin family of multifunctional galectins as targets of the protein kinases CK1, CK2, and PKA. Galectins are potent growth regulators able to bind both glycan and peptide motifs at intra- and extracellular sites.
Dieter Kübler, Jörg Seidler, Sabine André, Sonu Kumar, Reinhard Schwartz-Albiez, Wolf-Dieter Lehmann, Hans-Joachim Gabius   +6 more
openaire   +2 more sources

Small molecule modulators targeting protein kinase CK1 and CK2

European Journal of Medicinal Chemistry, 2019
Casein kinase (CK) is a type of conserved serine/threonine protein kinase that phosphorylates many important proteins in body. Researchers found that CK is involved in a variety of signaling pathways, and also plays an important role in inflammation, cancer, and nervous system diseases.
Yuting Qiao, Tingkai Chen, Hongyu Yang, Yao Chen, Hongzhi Lin, Wei Qu, Feng Feng, Wenyuan Liu, Qinglong Guo, Zongliang Liu, Haopeng Sun   +10 more
openaire   +2 more sources

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

Medicinal Research Reviews, 2011
AbstractFollowing the discovery of the human kinome, protein kinases have become the second most important group of drug targets as they can be modulated by small ligand molecules. Moreover, orally active protein kinase inhibitors have recently reached the market and there are many more in clinical trials.
Pérez, Daniel I., Gil, Carmen, Martínez Gil, Ana   +2 more
openaire   +3 more sources

The detection of creatine kinase isoenzyme CK1 in serum.

Annals of clinical and laboratory science, 1979
The brain isoenzyme of creatine kinase (CK) (EC 2.7.3.2) has been identified in the serum of 21 of 950 patients tested. Samples were received over a period of about 20 months. Analysis was performed by electrophoresis on agarose gel with isoenzyme bands visualized by fluorescence after enzyme coupled reactions producing NADH.
J E, Devine, R C, McDaniel
openaire   +1 more source

CK1 and GSK3 in the Drosophila and mammalian circadian clock.

Novartis Foundation symposium, 2004
Two kinases, DOUBLETIME and SHAGGY, have been shown to play a role in the circadian clock. DOUBLETIME, the Drosophila orthologue of casein kinase 1, can phosphorylate PERIOD in the cytoplasm and in the nucleus. This phosphorylation destabilizes PERIOD in both locations and sets patterns of both cytoplasmic accumulation and nuclear turnover. Cytoplasmic
Emily, Harms, Michael W, Young, Lino, Saez   +2 more
openaire   +1 more source

Inhibition of γ-secretase by the CK1 inhibitor IC261 does not depend on CK1δ

Bioorganic & Medicinal Chemistry Letters, 2010
CK1 and gamma-secretase are interesting targets for therapeutic intervention in the treatment of cancer and Alzheimer's disease. The CK1 inhibitor IC261 was reported to inhibit gamma-secretase activity. The question is: Does CK1 inhibition directly influence gamma-secretase activity?
Höttecke, Nicole, Liebeck, Miriam, Baumann, Karlheinz, Schubenel, Robert, Winkler, Edith, Steiner, Harald, Schmidt, Boris   +6 more
openaire   +3 more sources

The role of the casein kinase 1 (CK1) family in fungal infections

Molecular Biology Reports
The Casein kinase 1 (CK1) family, as an important member of the protein kinase family, exhibits high evolutionary conservation and is widely distributed in various cell types. CK1 plays critical roles in numerous cellular biological processes, and its abnormal expression is closely associated with the development and progression of various diseases ...
Meiling, Wu, Haolin, Zhang, Miao, Jia, Xingyu, Cao, Juan, Wang   +4 more
openaire   +2 more sources

MPEC 2024-C79 : 2024 CK1

The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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MPEC 2025-C52 : 2025 CK1

The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
openaire   +1 more source