Results 101 to 110 of about 303,943 (292)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Long-term renal function and hypertension in adult survivors of childhood sarcoma [PDF]

, 2018
Aim: Little data is available on long-term renal impairment in survivors from childhood sarcoma. We investigated the prevalence of renal impairment and hypertension after very long-term follow-up in survivors who reached adulthood after treatment for ...
Andreoli, Gianmarco, Bonci, Enea, Celani, Camilla, Marrucci, Oriana, Pedetti, Valeria, Schiavetti, Amalia, Varrasso, Giulia   +6 more
core   +1 more source

Impact of Renin‐Angiotensin System Inhibitors on Renal Function During Temporary Ileostomy Period in Rectal Cancer Patients: A Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This retrospective study explored the potential impact of renin–angiotensin system inhibitors (RASIs) on renal function during the ileostomy period in patients undergoing rectal cancer surgery. RASI use was associated with early postoperative renal impairment, and relatively slow recovery of renal function was observed until stoma closure.
Yusaku Shogen, Ryo Seishima, Masayoshi Monno, Satoru Morita, Kohei Shigeta, Koji Okabayashi, Yuko Kitagawa   +6 more
wiley   +1 more source

CKD-Associated Pruritus and Clinical Outcomes in Nondialysis CKD

Kidney Medicine
Itching is a frequent symptom experienced by people with chronic kidney disease (CKD). We investigated the associations of CKD-associated pruritus (CKD-aP) with clinical outcomes.This was a longitudinal cohort study.Patients from Brazil, France, and the United States enrolled in the Chronic Kidney Disease Outcomes and Practice Patterns Study (CKDopps ...
Jennifer S. Scherer, Charlotte Tu, Ronald L. Pisoni, Elodie Speyer, Antonio A. Lopes, Warren Wen, Frederique Menzaghi, Joshua Cirulli, Natalia Alencar de Pinho, Roberto Pecoits-Filho, Angelo Karaboyas, Antonio Lopes, Roberto Pecoits-Filho, Christian Combe, Christian Jacquelinet, Ziad Massy, Benedicte Stengel, Johannes Duttlinger, Danilo Fliser, Gerhard Lonnemann, Helmut Reichel, Takashi Wada, Kunihiro Yamagata, Ron Pisoni, Bruce Robinson, Viviane Calice da Silva, Ricardo Sesso, Elodie Speyer, Koichi Asahi, Junichi Hoshino, Ichiei Narita, Rachel Perlman, Friedrich Port, Nidhi Sukul, Michelle Wong, Eric Young, Jarcy Zee   +36 more
openaire   +4 more sources

Risk Factors for Small‐for‐Size Syndrome Grade B/C After Simultaneous Splenectomy in Adult Living‐Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
In a single‐center cohort of 577 adult LDLT recipients who underwent simultaneous splenectomy, clinically significant SFSS grade B/C (ILTS‐iLDLT‐LTSI 2023) occurred in 18.2% and was associated with inferior graft survival. Multivariate analysis identified MELD ≥ 30, NLR ≥ 4.5, and donor age ≥ 50 years as independent risk factors, which risk rising ...
Kyohei Yugawa, Takeo Toshima, Shinji Itoh, Takashi Motomura, Shohei Yoshiya, Norifumi Iseda, Tomoharu Yoshizumi   +6 more
wiley   +1 more source

An optimized 5/6 nephrectomy mouse model based on unilateral kidney ligation and its application in renal fibrosis research

Renal Failure, 2019
5/6 Nephrectomy (PNx) on rat and mouse mimics renal failure after loss of kidney function in human, and it has been widely used in CKD researches. However, existing methods for PNx model construction present high mortality of animals after modeling due ...
Rui-Zhi Tan, Xia Zhong, Jian-Chun Li, Yu-Wei Zhang, Ying Yan, Yuan Liao, Dan Wen, Hui Diao, Li Wang, Hong-Chun Shen   +9 more
doaj   +1 more source

Olmesartan-based monotherapy vs combination therapy in hypertension: A meta-analysis based on age and chronic kidney disease status. [PDF]

, 2017
Antihypertensive monotherapy is often insufficient to control blood pressure (BP). Several recent guidelines advocate for initial combination drug therapy in many patients. This meta-analysis of seven randomized, double-blind studies (N = 5888) evaluated
Bakris, George, Deedwania, Prakash, Reimitz, Paul-Egbert, Weber, Michael   +3 more
core   +1 more source

CKD Classification [PDF]

Journal of the American Society of Nephrology, 2009
The number of patients with ESRD is increasing worldwide. Despite recent advances in our understanding of the uremic state and improvements in the science and technology of renal replacement therapy, the morbidity and mortality of these patients is unacceptably high: More than 20% per year.
openaire   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Intervention to diminish dehydration and kidney damage among sugarcane workers

Scandinavian Journal of Work, Environment & Health, 2018
OBJECTIVE: The aim of this study was to assess the potential to reduce kidney function damage during the implementation of a water, rest, shade (WRS) and efficiency intervention program among sugarcane workers. METHODS: A WRS intervention program adapted
David H Wegman, Jenny Apelqvist, Matteo Bottai, Ulf Ekström, Ramón García-Trabanino, Jason Glaser, Christer Hogstedt, Kristina Jakobsson, Emmanuel Jarquín, Rebekah A I Lucas, Ilana Weiss, Catharina Wesseling, Theo Bodin, The Work Health and Efficiency (WE) Program Working Group   +13 more
doaj   +1 more source