ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso +3 more
wiley +1 more source
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source
Valorization of flaxseed Cyclolinopeptides from byproduct: Optimization of extraction and evaluation of cellular protective effects. [PDF]
Xu J +8 more
europepmc +1 more source
Moving beyond traditional trial‐and‐error, this review explores how integrating high‐throughput computational simulations, automated experimentation, and machine learning significantly accelerates perovskite solar cell development. By establishing intelligent, closed‐loop workflows, these synergistic technologies pave the way for fully autonomous ...
Yiming Wang +5 more
wiley +1 more source
Updates on Minimally Invasive Treatment of Adrenal Tumors. [PDF]
Akkus D, Berber E, Pérez-Soto RH.
europepmc +1 more source
Item Response Theory Analysis of the Classroom Level Adversity Scale
ABSTRACT The Classroom Level Adversity Scale (CLA) captures teachers' perceptions of the overall needs and challenges present in their classrooms. It reflects a collective classroom characteristic based on teacher report, providing insight into the degree of ecological risk teachers perceive when working with their students.
Allyson L. Hayward +2 more
wiley +1 more source
Hospital admissions among adolescents with local authority care experience or special educational needs in England: a population-based cohort study using linked administrative data from health, education and social care services. [PDF]
Blackburn RM +4 more
europepmc +1 more source
Red‐Pi: A Low‐Cost Red Teaming Platform for Water Infrastructure Security Assessment
ABSTRACT The water and wastewater sector faces growing cyber threats due to rapid digitalization and the use of IoT‐based control systems. Many utilities manage essential services that affect public health and the environment but do not have enough cybersecurity staff and cannot afford regular security tests.
Agustin Di Bartolo +5 more
wiley +1 more source
Longitudinal and Stability-Aware Analysis Reveals Treatment-Specific MicroRNA Response Signatures Following Immune-Reconstitution and B-Cell-Targeted Therapies in Multiple Sclerosis. [PDF]
Ata N +6 more
europepmc +1 more source

