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Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Poultry Farm Workers, Washington, USA, 2024 [PDF]

Emerging Infectious Diseases
Poultry workers in Washington, USA, were infected with highly pathogenic avian influenza A(H5N1) virus and recovered. The viruses were clade 2.3.4.4b genotype D1.1, closely related to viruses causing poultry outbreaks. Continued surveillance and testing
Yasuko Hatta, Juan A. De La Cruz, Theresa Murray, Brian Hiatt, Yunho Jang, Julia C. Frederick, Kristine A. Lacek, Juliana C. DaSilva, Dan Cui, Paul Carney, Jimma Liddell, Kay W. Radford, Natasha Burnett, Sabrina Schatzman, Pauline Trinh, Anna Unutzer, Elizabeth A. Pusch, Monique Johnson, Ha T. Nguyen, Benjamin L. Rambo-Martin, Larisa Gubareva, James Stevens, C. Todd Davis, Marie K. Kirby, Allison Black, Han Di   +25 more
doaj   +2 more sources

An overview of HPAI H5N1 clade 2.3.4.4b and its emerging threat in mainland Australia: Identified knowledge gaps [PDF]

One Health
The highly pathogenic avian influenza (HPAI) H5N1 virus, particularly clade 2.3.4.4b, is currently causing a panzootic. The threat of its incursion into mainland Australia is escalating, especially following its detection in Antarctica and recently on ...
Pan Zhang, C Raina MacIntyre
doaj   +2 more sources

Emerging threats of H5N1 clade 2.3.4.4b: cross-species transmission, pathogenesis, and pandemic risk [PDF]

Frontiers in Cellular and Infection Microbiology
H5N1 is a highly pathogenic avian influenza virus (HPAIV) with zoonotic potential, posing a significant risk to animal health, agriculture, and human public health. A particular strain, clade 2.3.4.4b, has spread globally and has been detected in various mammalian species—including cattle and a limited number of human cases—highlighting its potential ...
Riaz-M Azeem, Riaz-M Azeem, Ying-Shi Yang, Ying-Shi Yang, Siddique Sehrish, Siddique Sehrish, Chun-Wei Shi, Chun-Wei Shi, Gui-Lian Yang, Gui-Lian Yang, Suthar-Teerath Kumar, Suthar-Teerath Kumar, Wen-Tao Yang, Wen-Tao Yang, Chun-Feng Wang, Chun-Feng Wang   +15 more
openaire   +5 more sources

A pandemic toolbox for clade 2.3.4.4b A(H5N1) influenza virus risk assessment [PDF]

The Lancet Microbe
Belser JA.
openaire   +3 more sources

Genetic Characterization of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b, Antarctica, 2024 [PDF]

Emerging Infectious Diseases
In 2024, we sequenced highly pathogenic avian influenza virus A(H5N1) clade 2.3.4.4b genomes isolated from 5 brown skuas from James Ross Island, Antarctica. Phylogenetic analysis suggested the virus reached Antarctica through South America. Continued genetic surveillance will be critical to elucidate H5N1 virus transmission dynamics within Antarctica ...
Victor Neira, Naomi Ariyama, Pablo N. Castillo-Torres, Barbara Brito, Gabriela Muñoz, Karla B. Díaz Morales, Leonardo I. Almonacid, Benjamín Bennett-Laso, Barbara Berazay, Miloš Barták, Rafael Medina, Marcelo González-Aravena, Catalina Pardo-Roa   +12 more
openaire   +4 more sources

Transmission and pathogenicity in ferrets after experimental infection with HPAI clade 2.3.4.4b H5N1 viruses [PDF]

Journal of General Virology
A marked increase in the incidence of mortality amongst wild mammals attributed to infection with highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.4.4b viruses was observed in Europe in 2021. Neurological signs and high viral antigen levels in the brain of infected wild mammals indicate that the HPAI H5N1 virus causes severe disease in mammals ...
Luca Bordes, Nora M. Gerhards, Marit Roose, Sandra Venema, Marc Engelsma, Wim H.M. van der Poel, Evelien A. Germeraad, Nancy Beerens, Sandra Vreman   +8 more
openaire   +3 more sources

An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins [PDF]

Nature Communications
The continuous evolution and global spread of highly pathogenic avian influenza (HPAI) H5N1 viruses, particularly clade 2.3.4.4b, pose major challenges for pandemic preparedness.
Eduard Puente-Massaguer, Thales Galdino Andrade, Michael J. Scherm, Kirill Vasilev, Hassanein Abozeid, Alesandra J. Rodriguez, Joshua Yueh, Disha Bhavsar, John D. Campbell, Dong Yu, Richard J. Webby, Yoshihiro Kawaoka, Gabriele Neumann, Julianna Han, Andrew B. Ward, Florian Krammer   +15 more
doaj   +2 more sources

MF59-adjuvanted A/Astrakhan influenza vaccine induces cross-neutralizing H5N1 antibodies in ferrets against circulating clade 2.3.4.4b viruses [PDF]

npj Vaccines
The continued global spread of highly pathogenic avian influenza A(H5N1) viruses, particularly clade 2.3.4.4b, has increased zoonotic spillover risk and underscored the urgency of pandemic preparedness.
Karen Segovia, Raveen Rathnasinghe, Christopher Patton, Byungjoon Kwon, Ray A. Longstaff, Dirk Hofmann, Kulwinder K. Banger, Howard Xu, Marc Lacey, Ethan Settembre, Giuseppe Palladino, Alexander T. Kennedy, Nedzad Music   +12 more
doaj   +2 more sources

Current status of H5N1 influenza vaccines against clade 2.3.4.4b of H5N1 [PDF]

New Microbes and New Infections
Chiranjib Chakraborty, Manojit Bhattacharya, Arpita Das, Rao Zahid Abbas, Priyanka Choudhary, Om Prakash Choudhary   +5 more
openaire   +3 more sources

Ecology and environment predict spatially stratified risk of H5 highly pathogenic avian influenza clade 2.3.4.4b in wild birds across Europe [PDF]

Scientific Reports
Highly pathogenic avian influenza (HPAI) represents a threat to animal and human health, with the ongoing H5N1 outbreak within the H5 2.3.4.4b clade being one of the largest on record.
Sarah Hayes, Joe Hilton, Joaquin Mould-Quevedo, Christl A. Donnelly, Matthew Baylis, Liam Brierley   +5 more
doaj   +2 more sources