Results 81 to 90 of about 1,914 (161)

Molecular Characterization of H5N1 Clade 2.3.4.4b Virus in Vaccinated Layer Chickens

Viruses
The global emergence of the avian influenza virus (AIV) H5N1 clade 2.3.4.4b since 2016 has caused substantial losses in wild bird and poultry populations, along with heightened risks of transmission to humans and other mammals. Vaccination of poultry has been a key strategy to curb the virus’s spread and mitigate its socioeconomic impact.
Ahmed H. Salaheldin, Mustafa Ozan Atasoy, Juliane Lang, Ann Kathrin Ahrens, Anne Pohlmann, Mohammed A. Rohaim, Hatem S. Abd El-Hamid, Elsayed M. Abdelwhab   +7 more
openaire   +1 more source

Migratory Bird and Marine Mammal Surveillance Fails to Find Evidence for an HPAI H5N1 2.3.4.4b Incursion Into Australia in 2025

Influenza and Other Respiratory Viruses, Volume 20, Issue 6, June 2026.
Michelle Wille, Tobias A. Ross, Robyn Atkinson, David B. Boyle, Maureen Christie, Meagan L. Dewar, Tegan K. Douglas, Rachael Gray, Birgita Hansen, Rosalind Jessop, Lindall R. Kidd, Ila Marks, Patrick Mileto, Eric Miller, Matthew J. Neave, Sara Ryding, Duncan R. Sutherland, Hui Yu, Marcel Klaassen   +18 more
wiley   +1 more source

Efficacy of a multi-clade inactivated recombinant vaccine against the circulating highly pathogenic influenza A/H5N1 of clade 2.3.4.4b in poultry

Avian Pathology
Highly pathogenic avian influenza viruses (HPAIVs) have circulated globally since their emergence in China in 1996, infecting humans, poultry, wild birds, and mammals. During 2020–2021, H5N1 viruses of clade 2.3.4.4b spread widely, including to Egypt. Vaccination remains a key strategy to reduce clinical signs, mortality, and viral shedding in endemic ...
Wael M. Elfeil, Marwa Safwat, Ahmed Sedeek, Amany Adel, Heba Hassan, Mohamed A. Zain El-Abideen, Ibrahim Ali, Islam Hisham, Abdelsatar Arafa, Abdullah Selim, Manal Afifi, Momtaz A. Shaheen, Magdy F. Elkady, Walid H. Kilany   +13 more
openaire   +2 more sources

A Pan-H5N1 Multiepitope DNA Vaccine Construct Targeting Some Key Proteins of the Clade 2.3.4.4b Using AI-Assisted Epitope Mapping and Molecular Docking

Viruses
The presently used vaccines do not offer solid immunity/protection against the currently circulating strains of the H5N1 viruses. We aim to design a pan-H5N1 vaccine that protects birds against the presently circulating clade 2.3.4.4b in chickens.
Nithyadevi Duraisamy, Abid Ullah Shah, Mohd Yasir Khan, Mohammed Cherkaoui, Maged Gomaa Hemida   +4 more
doaj   +1 more source

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Nature Communications
Abstract The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, currently circulating H5N1 viruses contain multiple ...
David W. Hawman, Thomas Tipih, Eddie Hodge, E. Taylor Stone, Nikole Warner, Natalie McCarthy, Brian Granger, Kimberly Meade-White, Shanna Leventhal, Kiara Hatzakis, Stephanie Park, Karen Gaffney, Kyle Rosenke, Jesse H. Erasmus, Heinz Feldmann   +14 more
openaire   +3 more sources

Intranasally administered whole virion inactivated vaccine against clade 2.3.4.4b H5N1 influenza virus with optimized antigen and increased cross-protection

Virology Journal
The global spread, frequent antigenic changes, and pandemic potential of clade 2.3.4.4b highly pathogenic avian influenza H5N1 underscore the urgent need for robust cross-protective vaccines.
Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Seung-Ji Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi   +7 more
doaj   +1 more source

Attachment and replication of clade 2.3.4.4b influenza A (H5N1) viruses in human respiratory epithelium: an in-vitro study

The Lancet Microbe
Highly pathogenic avian influenza H5N1 viruses of the A/Goose/Guangdong/1/1996 lineage pose a global threat to wildlife, domestic animals, and humans. Cross-species transmission events to mammals, including humans, in the past 4 years highlight this threat.
Lisa Bauer, Lonneke Leijten, Matteo Iervolino, Varun Chopra, Laura van Dijk, Mark Power, Willemijn Rijnink, Mark Pronk, Monique Spronken, Mathis Funk, Rory D de Vries, Mathilde Richard, Thijs Kuiken, Debby van Riel   +13 more
openaire   +3 more sources

Unique phenomenon of H5 highly pathogenic avian influenza virus in China: co-circulation of Clade 2.3.4.4b H5N1 and H5N6 results in diversity of H5 Virus

Emerging Microbes and Infections
Recently, Clade 2.3.4.4b H5N1 virus has been widely prevalent globally. Although no outbreaks of Avian Influenza have occurred in poultry in China recently, Clade 2.3.4.4b H5 virus can still be isolated from wild birds, live poultry markets and ...
Xinkui Zhang, Yujia Yang, Xinyu Han, Dandan Wei, Beibei Niu, Qiuhong Huang, Yan Li, Huifang Yin, Xianpeng Zhang, Ming Liao, Weixin Jia   +10 more
doaj   +1 more source

Lack of respiratory droplet transmission of two recent human influenza A(H5N1) viruses in female ferrets

International Journal of Infectious Diseases
Objectives: Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) (HPAI H5N1) viruses are widespread globally and have transmitted from birds to dairy cattle at least four times in the United States, including once by a genotype B3.13 virus and three ...
Tong Wang, Chunyang Gu, Lizheng Guan, Asim Biswas, Tadashi Maemura, Hassanein H. Abozeid, Peter J. Halfmann, Gabriele Neumann, Amie J. Eisfeld, Yoshihiro Kawaoka   +9 more
doaj   +1 more source

Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza

npj Vaccines
Highly pathogenic avian influenzas (HPAIs) is a continuing public health threat. Here, we describe the development of plasmid-encoded H5N1 hemagglutinin antigens representing clades that have caused human zoonoses.
Ebony N. Gary, Nicholas J. Tursi, Casey E. Hojecki, Robert Vendramelli, Martina Tomirotti, Bryce Warner, Cory Livingston, Thang Truong, Yangcheng Gao, Sachchidanand Tiwari, Norbert Pardi, Darwyn Kobasa, David B. Weiner   +12 more
doaj   +1 more source