Results 171 to 180 of about 194,312 (252)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Comments on, "Effect of class IV LASER therapy along with low-dye kinesio-taping technique or plantar fascia stretching on pain, pain pressure threshold, and disability in individuals with plantar fasciitis: double-blinded randomized clinical trial". [PDF]

Lasers Med Sci
Başaran PÖ.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Correspondence: Comment on "Efficacy of erector spinae plane block versus intravenous tramadol for pain management in acute pancreatitis". [PDF]

Turk J Emerg Med
Ramesh S, Amrithanand VT.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Correction: Wahdan et al. One Health Monitoring of Resistant <i>Pseudomonas aeruginosa</i> in Aquatic, Poultry, and Human Sources: Virulence Traits and <i>bla</i>_SHV Gene Tracking. <i>Pathogens</i> 2025, <i>14</i>, 983. [PDF]

Pathogens
Wahdan A, Ezzat M, Emam A, Husseiny WA, Abou El-Atta M, Abd-Allah EM, Meligy AMA, Abdel-Raheem SM, Almathen F, Al-Shami S, Al-Sultan SI, Alfifi A, El-Deeb W, Abo Hashem ME.   +13 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

ChatGPT delivers mostly satisfactory but occasionally inaccurate and potentially unsafe answers to hip arthroscopy questions during the surgeon's learning curve. [PDF]

J Exp Orthop
Banke IJ, Fickert S, Landgraeber S, Möckel G, Zimmerer A, Ramadanov N, Osterberger T, Twardy V, Gebhart A, Pouessel F.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Comment on Shah and Ayala. Interpreting Stage-Dependent Changes in Semaglutide Response: From Patterns to Mechanisms. [PDF]

Diabetes
Ragozzino G, Cantelli MT, Fulgione E, Mattera E.   +3 more
europepmc   +1 more source