Results 61 to 70 of about 117,686 (204)

The Logic of Values Clarification

open access: yes, 2018
The author traces the origin of the Values Clarification movement in education in Carl Roger\u27s client-centered therapy and exposes its unwarranted extreme ethical stance.
Kazepides, A. C.
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Evaluating engaging clarification questions in information retrieval

open access: yes, 2023
Information-seeking systems for natural language questions often encounter a range of grammatically complex queries presented in unpredictable ways. Users often need to rephrase their questions in order to obtain a satisfactory answer, which can be both ...
Leila Tavakoli (18354756)
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Calcium phosphate flocs and the clarification of sugar cane juice from whole of crop harvesting [PDF]

open access: yes, 2015
Sugar cane biomass is one of the most viable feedstocks for the production of renewable fuels and chemicals.\ud Therefore, processing the whole of crop (WC) (i.e., stalk and trash, instead of stalk only) will increase the amount of available biomass for ...
Thai, Caroline C. D.   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Sewage clarification plant

open access: yes, 2013
The theme of the dissertation is structural survey of designed sewage clarification plant. The work deal about designed of reinforcement of the sewage clarification plant.
Stará, Anna
core   +2 more sources

Some problems with values clarification [PDF]

open access: yes, 1981
A critical analysis of the four approaches to the clarification of values from \u27Values Clarification: A Handbook of Practical Strategies for Teachers and Students\u27 by Sidney Simon, et ...
Robert Craig, Craig, Robert
core   +1 more source

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