Results 71 to 80 of about 117,686 (204)
Truthiness and Clarification Experiment 3
, 2023 This experiment will be a follow-up to Truthiness and Clarification Experiment 2 (https://doi.org/10.17605/OSF.IO/GRJ3C). Results of Experiment 2 showed that neither identification nor clarification resulted in statistically significant increases in the ...
Eryn Newman +4 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Clarification Dialogs: a tool for Question Answering disambiguation,
, 2007 We present a Question Answering system that provides a natural lan- guage interface to Databases. Our system uses clarification dialogues in order to disambiguate the possible meaning of user questions in natural language.
Quintano, Luis, Rodrigues, Irene Pimenta
core
Characterisation of sugarcane juice particles that influence the clarification process [PDF]
, 2012 Problems associated with processing whole sugarcane crop can be minimised by removing impurities during the clarification stage. As a first step, it is important to understand the colloidal chemistry of juice particles on a molecular level to assist ...
Doherty, William O.S. +1 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Moral Education versus Values Clarification
, 2018 The values clarification approach to moral education, is a deficient, if not faulty program for, despite claims to the contrary, the values clarification approach lacks the major requirements for an adequate moral educational program: the treatment of ...
Suttle, Bruce B.
core +2 more sources
Enzymes are proteins that catalyze chemical reactions. Some of them have been widely used to improve industrial processes and to produce food and beverages.
de Carvalho-Silva, Jônatas +2 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source