Results 91 to 100 of about 3,782,951 (354)

Local class field theory [PDF]

St. Petersburg Mathematical Journal, 2004
The author gives condition for a Henselian field \(F\) which imply that local class field theory is valid for \(F\) in the sense that for every finite Galois extension \(F_0\) of \(F\) the reciprocity map \(\text{Gal}(F_0/F) \to F^{\times}/N_{F_0/F}(F_0^{\times})\) induces an isomorphism of the projection to \(\text{Gal}(F_0/F)^{ab}\).
openaire   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Unitary quantization of a scalar charged field and Schwinger effect

Journal of High Energy Physics, 2020
Quantum field theory in curved spacetimes suffers in general from an infinite ambiguity in the choice of Fock representation and associated vacuum. In cosmological backgrounds, the requirement of a unitary implementation of the field dynamics in the ...
Luis J. Garay, Alberto García Martín-Caro, Mercedes Martín-Benito   +2 more
doaj   +1 more source

Abelian localp-class field theory

Mathematische Annalen, 1995
In the first section an abstract \(p\)-class field theory is developed. Assume that the ground field \(K\) possesses a distinguished Galois extension \(\widetilde {K}/K\) with the Galois group being an abelian pro- \(p\)-group. Then for a finite separable extension \(F/K\) Galois \(p\)- extensions \(L/F\) linearly disjoint with \(\widetilde {F}/F\), \(\
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

A new strategy to microscopic modeling of topological entanglement in polymers based on field theory

Nuclear Physics B, 2019
In this work a new strategy is proposed in order to build analytic and microscopic models of fluctuating polymer rings subjected to topological constraints.
Franco Ferrari
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A spectral theorem for a non-Archimedean valued field whose residue field is formally real

Extracta Mathematicae
In this paper, we will prove a spectral theorem for self-adjoint compactoid operators. Also, we will study the condition on which the coefficient field must be imposed.
K. Ishizuka
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source