Results 141 to 150 of about 12,130,137 (366)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

The Influence of Study Interest, Perceived Autonomy Support, and Student Enthusiasm on Class-Related Boredom of English Majors

SAGE Open
In Chinese universities, most English majors are taught by teachers, and students attend classes and do homework. Students are often passive in their study, which can make them lose study interest, negatively affect their study and cause boredom in class.
Guanyu Cui, Jing Zhou, Huilin Zhang, Tingting Hong, Yunjun Hu   +4 more
doaj   +1 more source

The Effect of Stad Model (Student Teams Achievement Division) Assisted by Smart Treasure Promotional Tools on Learning Interest of Grade IV Elementary School Students

Jurnal PAJAR (Pendidikan dan Pengajaran)
This research is motivated by the lack of innovation in the application of learning models and teaching aids which causes low student interest in learning in the learning process in class IV of SD Negeri Wonorejo 03.
Intan Dwi Cahyani, Anni Malihatul Hawa
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Self-interest versus collective action: understanding cross-class environmental perception, knowledge and behavior in Brazil

Papeles de Población, 2013
Este trabajo tiene como objetivo buscar evidencia de ecologismo entre la población pobre mediante dos preguntas: i) ¿El estrato socioeconómico y las condiciones objetivas del medio ambiente influencian positivamente la percepción sobre el medio ambiente,
Gilvan RAMALHO-GUEDES, Roberto LUIZ-DO-CARMO   +1 more
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Peculiarities of development of student-ecologists ' interest for intercultural communication in out-of-class activity

RUDN Journal of Ecology and Life Safety, 2011
The questions of developing of students' practical skills in intercultural communication in out-of-class activity with English-speaking persons are dwelt upon in this article. The experience of intercommunication, its skills and habbits are more and more
N N Malakhova
doaj  

DEVELOPMENT OF GOOGLE SITES LEARNING MEDIA TO INCREASE STUDENT LEARNING INTEREST IN GEOGRAPHY SUBJECTS AT SMAN 10 FAJAR HARAPAN BANDA ACEH

GeoEco
This study aims to determine the feasibility of Google Sites learning media and the effect of using Google Sites learning media in increasing student interest in learning.
Safinatun Najah, Ernawati Ernawati
doaj   +1 more source