Results 121 to 130 of about 1,474,265 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Contribution of Obesity to Polypharmacy in U.S. Older Adults. [PDF]

J Gen Intern Med
Chen AS, Chetty AK, Batsis JA, Lipska KJ, Hajduk AM.   +4 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Assessing waste reduction knowledge and practices in the operating room. [PDF]

Surg Open Sci
Wavering-Walters H, Class QA, Pandya LK.
europepmc   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Assessment of lower incisor position and symphysis dimensions among different skeletal patterns in the Chhattisgarh population. [PDF]

Bioinformation
Reshma E, Vadher V, Barapatre C, Baxi S, Singh S, Singh GB.   +5 more
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

An Exploratory Study of the Effects of a High School-University Collaborative Program on Learning Motivation and Professional Understanding among Students Aspiring to Enter Medical School. [PDF]

Juntendo Med J
Ogawa T, Nishizaki Y, Sekine M, Ogura K, Orita H, Tomiki Y.   +5 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Patterns of polysubstance use among people who use drugs on an American Indian reservation of a southern plains Tribal Nation. [PDF]

Harm Reduct J
Schneider KE, Allen ST, O'Rourke A, Reid M, Conrad M, Garrett B, Hautala D, Lewis K, Lewis S, Wilson L, Walls M.   +10 more
europepmc   +1 more source