Results 161 to 170 of about 137,516 (336)

Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation. [PDF]

Biomedicines, 2023
Režić Mužinić N, Markotić A, Pavelin S, Polančec D, Buljubašić Šoda M, Bralić A, Šoda J, Mastelić A, Mikac U, Jerković A, Rogić Vidaković M.   +10 more
europepmc   +1 more source

Classical monocyte ontogeny dictates their functions and fates as tissue macrophages

Immunity
Classical monocytes (CMs) are ephemeral myeloid immune cells that circulate in the blood. Emerging evidence suggests that CMs can have distinct ontogeny and originate from either granulocyte-monocyte- or monocyte-dendritic-cell progenitors (GMPs or MDPs). Here, we report surface markers that allowed segregation of murine GMP- and MDP-derived CMs, i.e.,
Trzebanski, Sebastien, Kim, Jung-Seok, Larossi, Niss, Raanan, Ayala, Kancheva, Daliya, Bastos, Jonathan, Haddad, Montaser, Solomon, Aryeh, Sivan, Ehud, Aizik, Dan, Kralova, Jarmila Sekeresova, Gross-Vered, Mor, Boura-Halfon, Sigalit, Lapidot, Tsvee, Alon, Ronen, Movahedi, Kiavash, Jung, Steffen   +16 more
openaire   +4 more sources

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients. [PDF]

, 2018
Background:The number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to ...
Abdalla, Basmah, Bunnapradist, Suphamai, Danovitch, Gabriel, Groysberg, Victoria, Korin, Yael, Liang, Emily C, Lum, Erik, Pham, Phuong-Thu, Reed, Elaine F, Rossetti, Maura, Schaenman, Joanna, Sidwell, Tiffany, Sunga, Gema, Vangala, Sitaram   +13 more
core   +1 more source

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation

Advanced Science, EarlyView.
ASXL1's long IDR encodes an electrostatic “basic platform + acidic brake” that autoregulates condensation. Truncation at a clinical hotspot lifts this brake, forming condensates that retarget BRD2, remodel local chromatin accessibility, and impair neutrophil maturation.
Xiao Fang, Qiwei Li, Wenqing Zhang
wiley   +1 more source

Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis

Bone Research
Bone marrow lesions (BML) are early signs of osteoarthritis (OA) and are strongly correlated with the deterioration of cartilage lesions. Single-cell RNA sequencing (scRNA-seq) analyses were performed on BM from non-BML and BML areas and articular ...
Pengqiang Lou, Xiaoyan Lu, Mengyin Li, Yue Yao, Xin Shao, Dan Shou, Xiaohui Fan, Peijian Tong, Yang Zhang   +8 more
doaj   +1 more source

Numbers and phenotype of non-classical CD14dimCD16+ monocytes are predictors of adverse clinical outcome in patients with coronary artery disease and severe SARS-CoV-2 infection [PDF]

, 2020
Karin Anne Lydia Mueller, Carolin Langnau, Manina Günter, Simone Pöschel, Sarah Gekeler, Álvaro Petersen-Uribe, Klaus‐Peter Kreißelmeier, Karin Klingel, Hans Bösmüller, Bo Li, Philippa Jaeger, Tatsiana Castor, Dominik Rath, Meinrad Gawaz, Stella E. Autenrieth   +14 more
openalex   +1 more source

The anti-inflammatory LncRNA Heat4 interacts with the pro-inflammatory protein IP1 in non-classical monocytes promoting vascular regeneration [PDF]

, 2023
Jasmin M. Kneuer, M. Winkler, Tim Meinecke, Maximilian N. Möbius-Winkler, R. Weiß, Jan Haas, Alexander Kögel, K.-P. Kresoja, S. Rosch, Stephan Erbe, K Kokot, Paulina Stürzebecher, Tania Garfias‐Veitl, Stephan von Haehling, Till Keller, Hölger Thiele, Philipp Lurz, Thimoteus Speer, Ulrich Laufs, Jes‐Niels Boeckel   +19 more
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses [PDF]

, 2016
et al,, Randolph, Gwendalyn J
core   +2 more sources