Results 141 to 150 of about 1,881,470 (286)

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway [PDF]

, 2002
HMGB1, a non-histone nuclear factor, acts extracellularly as a mediator of delayed endotoxin lethality, which raises the question of how a nuclear protein can reach the extracellular space.
S. Gardella, D. Ferrera, M. E. Bianchi, Anna Rubartelli, A. Rubartelli, Lavinia V Lotti, Denise Ferrera, Marco E Bianchi, Stefania Gardella, C. Andrei, Maria R Torrisi, Cristina Andrei, TORRISI, Maria Rosaria, LOTTI, Lavinia Vittoria   +13 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Monocytes in human kidney. [PDF]

, 2016
(a) Gating strategy with the markers used to identify monocytes and macrophages. The boxes are color-coded with classical monocytes in blue, non-classical in green and intermediate in red.
Barbara Neudert (2575720), Dario A. Leone (2575735), Renate Kain (606861), Theresa Waidacher (2575729), Nicolas Kozakowski (2575738), Christoph Kornauth (2575732), Agnes G. Loeffler (2575726), Andrea Haitel (627354), Andrew J. Rees (2575723)   +8 more
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progression

BMC Infectious Diseases
Background In tuberculosis (TB) infection, monocytes play a crucial role in regulating the balance between immune tolerance and immune response through various mechanisms. A deeper understanding of the roles of monocyte subsets in TB immune responses may
Rong Ma, Wanzhong Yang, Wei Guo, Honglai Zhang, Zemin Wang, Zhaohui Ge   +5 more
doaj   +1 more source

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis

Scientific Reports, 2017
Monocytes/macrophages are critical in systemic and local inflammation in giant cell arteritis (GCA) and possibly in clinically overlapping polymyalgia rheumatica (PMR). Therefore, we aimed to understand the contribution of monocyte subsets and the CX3CR1-
Yannick van Sleen, Qi Wang, Kornelis S. M. van der Geest, Johanna Westra, Wayel H. Abdulahad, Peter Heeringa, Annemieke M. H. Boots, Elisabeth Brouwer   +7 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Changes in monocyte subsets are associated with an increased risk of AAA and are surrogate markers for AAA morphology in patients with late-stage disease

Frontiers in Immunology
IntroductionMonocytes play a role in the pathology of abdominal aortic aneurysm (AAA) and can display immunophenotypic heterogeneity. Alterations in monocyte subsets are associated with cardiovascular risk, but their profile in AAA is poorly understood ...
Bianca Hamann, Anna Klimova, Marvin Kapalla, David M. Poitz, Albert Busch, Henning Morawietz, Christian Reeps, Anja Hofmann   +7 more
doaj   +1 more source

Circulating CD14+CD16- classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients.

Journal of Molecular and Cellular Cardiology, 2019
AIMS Mouse studies have established distinct monocyte subtypes that participate in the process of atherosclerotic lesion formation. The pro-inflammatory Ly6Chigh monocyte subtype actively contributes to murine plaque progression and destabilization. Also
John A. L. Meeuwsen, J. D. de Vries, Amerik van Duijvenvoorde, Saskia van der Velden, S. W. van der Laan, I. V. van Koeverden, S. M. van de Weg, G. D. de Borst, M. D. de Winther, J. Kuiper, G. Pasterkamp, I. Hoefer, S. D. de Jager   +12 more
semanticscholar   +1 more source

Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment

PLOS ONE, 2019
Classic Hodgkin lymphoma (CHL) characteristically shows few malignant cells in a microenvironment comprised of mixed inflammatory cells. Although CHL is associated with a high cure rate, recent studies have associated poor prognosis with absolute monocyte count in peripheral blood and increased monocyte/macrophages in involved lymph nodes.
Ginell R. Post, Youzhong Yuan, Emily R. Holthoff, Charles M. Quick, Steven R. Post   +4 more
openaire   +3 more sources