Results 241 to 250 of about 137,516 (336)

Fasting plasma methylglyoxal concentrations are associated with higher numbers of circulating intermediate and non-classical monocytes but with lower activation of intermediate monocytes: the Maastricht Study. [PDF]

J Endocrinol Invest
Zhang X, van Greevenbroek MMJ, Scheijen JLJM, Eussen SJPM, Kelly J, Stehouwer CDA, Schalkwijk CG, Wouters K.   +7 more
europepmc   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP-1) Regulates Functional Markers in Intermediate and Non-Classical Monocytes. [PDF]

Cancers (Basel)
Moyano A, Colado A, Amarillo ME, De Matteo E, Preciado MV, Borge M, Chabay P.   +6 more
europepmc   +1 more source

GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation. [PDF]

Cell Rep, 2021
Kaur K, Bachus H, Lewis C, Papillion AM, Rosenberg AF, Ballesteros-Tato A, León B.   +6 more
europepmc   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

mTORC1 activation in presumed classical monocytes: observed correlation with human size variation and neuropsychiatric disease. [PDF]

Aging (Albany NY)
Berner K, Oz N, Kaya A, Acharjee A, Berner J.   +4 more
europepmc   +1 more source

Increased Abundances of CD16⁺ Non-Classical Monocytes Accompany with Elevated Monocytic PD-L1 and CD4⁺ T Cell Disturbances in Oropharyngeal Cancer. [PDF]

Biomedicines, 2022
Idel C, Polasky C, Ribbat-Idel J, Loyal K, Perner S, Rades D, Bruchhage KL, Pries R.   +7 more
europepmc   +1 more source

Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis [PDF]

Yosta Vegting, Aldo Jongejan, Annette E. Neele, Nike Claessen, Gal Sela, Koen H.M. Prange, Jesper Kers, Joris J. T. H. Roelofs, Joost W van der Heijden, Onno J. de Boer, Ester B. M. Remmerswaal, Liffert Vogt, Fréderike J. Bemelman, Menno P.J. de Winther, Perry D. Moerland, Marc Hilhorst   +15 more
openalex   +1 more source

Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous [PDF]

, 2015
Ratnadeep Mukherjee, Pijus Barman, Pravat Kumar Thatoi, Rina Tripathy, Bidyut Kumar Das, Balachandran Ravindran   +5 more
openalex   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source