Results 261 to 270 of about 1,881,470 (286)

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

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Neutrophilic asthma features increased airway classical monocytes

Clinical & Experimental Allergy, 2020
Monocytes and macrophages are critical innate immune cells of the airways. Despite their differing functions, few clinical studies discriminate between them and little is known about their regulation in asthma.
Natalie M. Niessen, K. Baines, J. Simpson, H. Scott, Ling Qin, P. Gibson, M. Fricker   +6 more
semanticscholar   +4 more sources

Transcriptomic Network Support Distinct Roles of Classical and Non-Classical Monocytes in Human

International Reviews of Immunology, 2014
Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistently overexpressed either in ...
Christian Jörgensen, Florence Apparailly, Isabelle Duroux-Richard   +2 more
exaly   +3 more sources

Non-classical monocytes in cardiovascular physiology and disease.

American Journal of Physiology - Cell Physiology, 2021
Monocytes are a heterogeneous cell population of innate immune cells with distinct cell surface markers that help them in carrying out different functions.
S. Tahir, S. Steffens
semanticscholar   +1 more source

The stimulation of an osteogenic response by classical monocyte activation

Biomaterials, 2011
The monocyte/macrophage system plays a central role in host defense, wound healing and immune regulation at biomaterial surfaces. Monocytes can be classically and alternatively activated, and can be stimulated differently in response to variations in biomaterial surface properties.
Omar M, Omar, Cecilia, Granéli, Karin, Ekström, Camilla, Karlsson, Anna, Johansson, Jukka, Lausmaa, Cecilia Larsson, Wexell, Peter, Thomsen   +7 more
openaire   +2 more sources

Integrin αMβ2 is differently expressed by subsets of human osteoclast precursors and mediates adhesion of classical monocytes to bone [PDF]

Experimental Cell Research, 2017
Bone-degrading osteoclasts are formed through fusion of their monocytic precursors. In the population of human peripheral blood monocytes, three distinct subsets have been identified: classical, intermediate and non-classical monocytes.
T J De Vries, Ton Schoenmaker, Yixuan Cao   +2 more
exaly   +2 more sources

Prevalence of classical CD14++/CD16 − but not of intermediate CD14++/CD16 + monocytes in hypoalphalipoproteinemia

International Journal of Cardiology, 2013
Giulia Chiesa, Angela Pirillo, Giuseppe Danilo Norata   +2 more
exaly   +4 more sources

Ruxolitinib Treatment Induces a Transition of Classical to Non-Classical Monocytes in Patients with Myelofibrosis

Blood, 2015
Abstract Introduction: Myelofibrosis (MF) is a clonal myeloproliferative neoplasm that develops de novo (primary myelofibrosis) or transforms from polycythemia vera or essential thrombocytosis. MF is characterized by stem cell-derived clonal myeloproliferation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly ...
Sanja Prijic, Taghi Manshouri, Ying Zhang, Ivo Veletic, Xiaorui Zhang, Joseph E Bove, Zeev Estrov, Srdan Verstovsek   +7 more
openaire   +1 more source

Classical Monocytes Shuttling for Precise Delivery of Nanotherapeutics to Glioblastoma

Advanced Healthcare Materials
AbstractGlioblastoma (GBM) is the most aggressive brain tumor for which current therapies have limited efficacy. Immunosuppression and difficulties in accessing tumors with therapeutic agents are major obstacles for GBM treatments. Classical monocytes (CMs) possess the strongest infiltration among myeloid cells recruited into tumors during ...
Congwen Li, Congyi Niu, Lin Chen, Baichao Yu, Feifei Luo, Jingbo Qie, Hui Yang, Jiawen Qian, Yiwei Chu   +8 more
openaire   +2 more sources