Results 51 to 60 of about 1,110,361 (272)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The changing conception of measurement in education and psychology [PDF]

open access: yes, 1986
Since the era of Binet and Spearman, classical test theory and the ideal of the standard test have gone hand in hand, in part because both are based on the same paradigm of experimental control by manipulation and randomization.
Linden, Wim J. van der
core   +5 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Web application for the analysis of assessment tests

open access: yesMillenium, 2018
Introduction: An assessment test enables the evaluation of an individual’s competence or ability. Such tests are important for both teaching and professional training institutions, as well as for the recruiting of human resources in the enterprise ...
Paula Prata   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Comparison of Classical and Modern Measures of Internal Consistency

open access: yesFrontiers in Psychology, 2019
Three measures of internal consistency – Kuder-Richardson Formula 20 (KR20), Cronbach’s alpha (α), and person separation reliability (R) – are considered.
Pasquale Anselmi   +2 more
doaj   +1 more source

Emergent matter from 3d generalised group field theories

open access: yes, 2010
We identify classical solutions of a generalised group field theory model in 3 dimensions, and study the corresponding perturbations, deriving their effective dynamics. We discuss their interpretation as emergent matter fields. This allows us, on the one
Di Mare, Alessandro, Oriti, Daniele
core   +2 more sources

Advances in item response theory and applications: an introduction [PDF]

open access: yes, 1982
Test theories can be divided roughly into two categories. The first is classical test theory, which dates back to Spearman’s conception of the observed test score as a composite of true and error components, and which was introduced to psychologists at ...
Hambleton, Ronald K.   +1 more
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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