Results 71 to 80 of about 1,110,361 (272)

Development of the Paranormal and Supernatural Beliefs Scale using classical and modern test theory

open access: yesBMC Psychology, 2021
Background This study describes the construction and validation of a new scale for measuring belief in paranormal phenomena. The work aims to address psychometric and conceptual shortcomings associated with existing measures of paranormal belief.
Charlotte E. Dean   +5 more
doaj   +1 more source

Noether symmetries, energy-momentum tensors and conformal invariance in classical field theory

open access: yes, 2009
In the framework of classical field theory, we first review the Noether theory of symmetries, with simple rederivations of its essential results, with special emphasis given to the Noether identities for gauge theories.
Arnowitt R. L.   +6 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Classical Test Theory and Item Response Theory in Measuring Validity of Peer-Grading in Massive Open Online Courses

open access: yesВопросы образования, 2018
The article presents the results of research on validity of peer-review assignments in massive open online courses within the framework of classical test theory (CTT) and item response theory (IRT).
Daria Kravchenko
doaj   +1 more source

From relativistic to quantum universe: Observation of a spatially-discontinuous particle dynamics beyond relativity

open access: yes, 2018
We perform an experimental test where we directly observe light-induced electron transitions with a macroscopic spatial discontinuity. The effect is related to the fundamental indivisibility of macroscopic orbit-like quantum states reminiscent of so ...
Emelyanov, Sergey A.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Investigating Different Theory-Based Differential Item Functioning Methods Under Different Scoring Situations

open access: yesInternational Journal of Assessment Tools in Education, 2017
This study intended to investigate theoperations of various theory-based Differential Item Functioning (DIF) methodsunder different scoring situations.
Hüseyin Selvi, Devrim Alıcı
doaj   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

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