Results 41 to 50 of about 12,640,498 (274)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Web application for the analysis of assessment tests

Millenium, 2018
Introduction: An assessment test enables the evaluation of an individual’s competence or ability. Such tests are important for both teaching and professional training institutions, as well as for the recruiting of human resources in the enterprise ...
Paula Prata, Luís Duarte, Maria Eugénia Ferrão   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Comparison of Classical and Modern Measures of Internal Consistency

Frontiers in Psychology, 2019
Three measures of internal consistency – Kuder-Richardson Formula 20 (KR20), Cronbach’s alpha (α), and person separation reliability (R) – are considered.
Pasquale Anselmi, Daiana Colledani, Egidio Robusto   +2 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Test Submission

This is a sample submission generated by Vireo to test the repository deposit ...
Submitter, Test
core   +5 more sources

On the complementarity of classical test theory and item response models: item difficulty estimates and computerized adaptive testing

Ensaio, 2015
This study aims to provide statistical evidence of the complementarity between classical test theory and item response models for certain educational assessment purposes.
Patrícia Costa, Maria Eugénia Ferrão
doaj   +1 more source

Validation of the Chinese EORTC chronic lymphocytic leukaemia module – application of classical test theory and item response theory

Health and Quality of Life Outcomes, 2020
Purpose The association of chronic lymphocytic leukemia (CLL) with health-related quality of life (HRQoL) is rarely studied globally. This study evaluated the psychometric properties of the EORTC-Chronic Lymphocytic Leukaemia (CLL17 [phase III]) module ...
Dong Dong, Jun Jin, Simone Oerlemans, Siyue Yu, Shenmiao Yang, Jianfeng Zhu, Richard Huan Xu   +6 more
doaj   +1 more source