Results 91 to 100 of about 126,267 (387)
Human Coronavirus 229E Uses Clathrin-Mediated Endocytosis as a Route of Entry in Huh-7 Cells
BiomoleculesHuman coronavirus 229E (HCoV-229E) is an endemic coronavirus responsible for approximately one-third of “common cold” cases. To infect target cells, HCoV-229E first binds to its receptor on the cell surface and then can follow different pathways ...
Sabina Andreu +3 more
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Clathrin modulates vesicle scission, but not invagination shape, in yeast endocytosis
eLife, 2016 In a previous paper (Picco et al., 2015), the dynamic architecture of the protein machinery during clathrin-mediated endocytosis was visualized using a new live imaging and particle tracking method. Here, by combining this approach with correlative light
Wanda Kukulski +4 more
doaj +1 more source
Clathrin–Protein Interactions [PDF]
Traffic, 2002 There is a complex network of protein–protein and protein–lipid interactions that underlie clathrin‐mediated vesicular traffic in all compartmentalized cells from yeast to man. Major progress has been made in the determination of the three‐dimensional structures of many of the components.
openaire +3 more sources
Advanced Functional Materials, EarlyView.A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao +8 more
wiley +1 more source
Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]
, 2016 Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E. +8 more
core +2 more sources
CellsThe Sprouty (SPRY) proteins are evolutionary conserved modulators of receptor tyrosine kinase (RTK) signaling. SPRY2 inhibits fibroblast growth factor (FGF) signaling, whereas it enhances epidermal growth factor (EGF) signaling through inhibition of EGF ...
Barbara Hausott +6 more
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The Role of Molecular Chaperones in Clathrin Mediated Vesicular Trafficking
Frontiers in Molecular Biosciences, 2015 The discovery that the 70 kD ‘uncoating ATPase’, which removes clathrin coats from vesicles after endocytosis, is the constitutively expressed Hsc70 chaperone was a surprise.
Rui eSousa, Eileen M Lafer
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Advanced Functional Materials, EarlyView.Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang +9 more
wiley +1 more source
Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]
, 1993 The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna +5 more
core +3 more sources
Novel clathrin activity: developments in health and disease
Biomolecular Concepts, 2014 Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health
Ybe Joel A.
doaj +1 more source