Rule-based modelling provides an extendable framework for comparing candidate mechanisms underpinning clathrin polymerisation [PDF]
Polymerisation of clathrin is a key process that underlies clathrin-mediated endocytosis. Clathrin-coated vesicles are responsible for cell internalization of external substances required for normal homeostasis and life –sustaining activity.
A Banerjee +41 more
core +2 more sources
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker +16 more
wiley +1 more source
Novel clathrin activity: developments in health and disease
Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health
Ybe Joel A.
doaj +1 more source
Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin
Background Hermansky-Pudlak syndrome (HPS) is a disorder of lysosome-related organelle biogenesis characterized by oculocutaneous albinism and prolonged bleeding.
Gahl William A +6 more
doaj +1 more source
The Ins and Outs of Antigen Uptake in B cells
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field.
Adam Nathan McShane, Dessislava Malinova
doaj +1 more source
Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna +5 more
core +3 more sources
Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity
Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading.
Z. Farsi +8 more
semanticscholar +1 more source
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid +6 more
wiley +1 more source
Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]
Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E. +8 more
core +2 more sources
Clathrin-mediated endocytosis is a candidate entry sorting mechanism for Bombyx mori cypovirus
Bombyx mori cypovirus (BmCPV), a member of the Reoviridae, specifically infects silkworms and causes extensive economic losses to the sericulture industry. To date, the entry mechanism of BmCPV into cells is unclear.
Fei Chen +9 more
semanticscholar +1 more source

