Results 91 to 100 of about 134,599 (345)

Rule-based modelling provides an extendable framework for comparing candidate mechanisms underpinning clathrin polymerisation [PDF]

, 2018
Polymerisation of clathrin is a key process that underlies clathrin-mediated endocytosis. Clathrin-coated vesicles are responsible for cell internalization of external substances required for normal homeostasis and life –sustaining activity.
A Banerjee, A Fotin, A Fotin, A Fotin, AJ Jin, AS Perelson, B Goldstein, BI Shraiman, BM Pearse, BM Pearse, D Leyton-Puig, EJ Ungewickell, F Ferreira, GJ Doherty, HT McMahon, I Pastan, J Colvinr, JD Wilbur, M Falk, M Girard, M Lampe, M Muthukumar, M Saleem, MI Monine, MW Sneddon, N Jung, O Avinoam, O Sorokina, PK Sorger, PN Dannhauser, PN Dannhauser, R Matthews, R Nossal, S Marino, S Schein, SM Smith, T Böcking, T Kirchhausen, V Danos, WK Otter den, WK Otter den, Y Saheki   +41 more
core   +2 more sources

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Novel clathrin activity: developments in health and disease

Biomolecular Concepts, 2014
Clathrin self-assembles into a coat around vesicles filled with cargo such as nutrients, hormones, and proteins destined for degradation. Recent developments indicate clathrin is not a specialist, but is involved in different processes relevant to health
Ybe Joel A.
doaj   +1 more source

Association of the Hermansky-Pudlak syndrome type-3 protein with clathrin

BMC Cell Biology, 2005
Background Hermansky-Pudlak syndrome (HPS) is a disorder of lysosome-related organelle biogenesis characterized by oculocutaneous albinism and prolonged bleeding.
Gahl William A, Boissy Raymond E, Mommaas Mieke, Dorward Heidi, Westbroek Wendy, Helip-Wooley Amanda, Huizing Marjan   +6 more
doaj   +1 more source

The Ins and Outs of Antigen Uptake in B cells

Frontiers in Immunology, 2022
A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of these processes to pathology, and outstanding questions in the field.
Adam Nathan McShane, Dessislava Malinova
doaj   +1 more source

Mutations in human dynamin block an intermediate stage in coated vesicle formation [PDF]

, 1993
The role of human dynamin in receptor-mediated endocytosis was investigated by transient expression of GTP-binding domain mutants in mammalian cells. Using assays which detect intermediates in coated vesicle formation, the dynamin mutants were found to ...
Damke, Hanna, Meyerowitz, Elliot M., Redelmeier, Thomas E., Schmid, Sandra L., Tisdale, Ellen J., van der Bliek, Alexander M.   +5 more
core   +3 more sources

Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity

eLife, 2018
Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading.
Z. Farsi, Sindhuja Gowrisankaran, Matija Krunić, Burkhard Rammner, A. Woehler, E. Lafer, C. Mim, R. Jahn, Ira Milosevic   +8 more
semanticscholar   +1 more source

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source

Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner [PDF]

, 2016
Cannabinoid receptor interacting protein 1a (CRIP1a) is a CB1 receptor (CB1R) distal C-terminus-associated protein that modulates CB1R signaling via G proteins, and CB1R down-regulation but not desensitization (Blume et al.
Bass, Caroline E., Blumes, Lawrence C, Chen, Rong, Howlett, Allyn C., Leone-Kabler, Sandra, Luessen, Deborah J., Lyons, Erica, Marrs, Glenn S., Selley, Dana E.   +8 more
core   +2 more sources

Clathrin-mediated endocytosis is a candidate entry sorting mechanism for Bombyx mori cypovirus

Scientific Reports, 2018
Bombyx mori cypovirus (BmCPV), a member of the Reoviridae, specifically infects silkworms and causes extensive economic losses to the sericulture industry. To date, the entry mechanism of BmCPV into cells is unclear.
Fei Chen, Liyuan Zhu, Yiling Zhang, Dhiraj Kumar, G. Cao, Xiaolong Hu, Zi Liang, Sulan Kuang, Renyu Xue, C. Gong   +9 more
semanticscholar   +1 more source