Results 121 to 130 of about 134,599 (345)
Advanced Science, EarlyView.Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Clathrin Heavy Chain Knockdown Impacts CXCR4 Signaling and Post-translational Modification
Frontiers in Cell and Developmental Biology, 2019 Recent research has implicated endocytic pathways as important regulators of receptor signaling. However, the role of endocytosis in regulating chemokine CXC receptor 4 (CXCR4) signaling remains largely unknown.
Maxwell S. DeNies +8 more
doaj +1 more source
Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth. [PDF]
, 2018 The ancient morphoregulatory hormone auxin dynamically realigns dedicated cellular processes that shape plant growth under prevailing environmental conditions. However, the nature of the stress-responsive signal altering auxin homeostasis remains elusive.
de Souza, Amancio +9 more
core +2 more sources
Advanced Science, EarlyView.A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang +17 more
wiley +1 more source
Clathrin Coat Disassembly Illuminates the Mechanisms of Hsp70 Force Generation
Nature Structural &Molecular Biology, 2016 Hsp70s use ATP hydrolysis to disrupt protein-protein associations and to move macromolecules. One example is the Hsc70- mediated disassembly of the clathrin coats that form on vesicles during endocytosis.
R. Sousa +6 more
semanticscholar +1 more source
Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides
Advanced Science, EarlyView.This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das +13 more
wiley +1 more source
Endocytosis and Enamel Formation
Frontiers in Physiology, 2017 Enamel formation requires consecutive stages of development to achieve its characteristic extreme mineral hardness. Mineralization depends on the initial presence then removal of degraded enamel proteins from the matrix via endocytosis.
Cong-Dat Pham +7 more
doaj +1 more source
The developmental cell biology of Trypanosoma brucei [PDF]
, 2005 Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core +2 more sources
Journal of Biological Chemistry, 2014 Background: Exosomes can transfer information between cells and facilitate tumor development. Results: PC12 cell-derived exosomes enter into BMSCs through clathrin-mediated endocytosis and macropinocytosis, and decrease the expression of TGFβRII and TPM1
Tian Tian +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee +8 more
wiley +1 more source