Results 171 to 180 of about 63,639 (257)

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, Volume 38, Issue 17, 20 March 2026.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Itaconate reduces viral endocytosis by targeting Cys128 of the adaptor-related protein complex 1 gamma 1 subunit in the host, providing a novel target for antiviral drug development. [PDF]

Mol Biomed
Deng X, Chen H, Huang Z, He R, Rao Q, Xu L, Xu Z, Zhao N, Peng Y, Li M, Liu X, Ma T, Cui X, Wang C.   +13 more
europepmc   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, Volume 38, Issue 16, 17 March 2026.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source

Clathrin mediated endocytosis targeting chimera for targeted membrane proteins degradation and enhance CAR-T cell anti-tumor therapy. [PDF]

Theranostics
Li Y, Zhou Z, Lv Y, Hu H, Chen M, Lei K, Gong C, Liu J, Yang L, Huang L, Liu W, Li J, Ye M, Zhu X, Huang K.   +14 more
europepmc   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, Volume 38, Issue 13, 3 March 2026.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

A cluster of acidic residues in the cytoplasmic domain of SARS-CoV-2 Spike is required for virion-incorporation and infectivity. [PDF]

PLoS One
Stoneham CA, Singh R, De Leon A, Tafelmeyer P, Acosta F, Fuori A, Anderson M, Ramirez PW, Schwartzer-Sperber HS, Pillai S, Lewinski MK, Guatelli J.   +11 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, Volume 13, Issue 16, 18 March 2026.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

<i>Ec</i>CXCR4b influences RGNNV proliferation by interacting with the RGNNV capsid protein. [PDF]

mBio
Hua X, Li C, Yu Y, Lu Y, Ye J, Liu X.
europepmc   +1 more source

Microenvironment‐Guided Evolution of ssDNA‐SWCNT Probes for Selective Recognition of Aggressive Prostate Cancer Phenotypes

Advanced Science, Volume 13, Issue 17, 23 March 2026.
Random ssDNA–SWCNT(single strand DNA‐single walled carbon nanotube) library is functionally screened and evolved using high‐throughput 3D prostate tumor spheroids via iterative positive and negative selection, enabling the identification of NIR‐II fluorescent ssDNA‐SWCNT nanoprobe specific for prostate cancer.
Dakyeon Lee, Seok‐Hyeon Lee, Yunseo Jung, Jeongho Lee, Min‐Seo Choi, SaeOck Oh, Sungjee Kim, Byoung Soo Kim, Sanghwa Jeong   +8 more
wiley   +1 more source